• Product NameDMAP1 (Phospho-Tyr246) Antibody
• Host SpeciesRabbit
• ClonalityPolyclonal
• PurificationThe antibody was purified from rabbit serum by affinity purification via sequential chromatography on phospho-peptide and non-phospho-peptide affinity columns.
• ApplicationsWB
• Species ReactivityHMR
• SpecificityDMAP1(Phospho-Tyr246) Antibody detects endogenous levels of DMAP1 only when phosphorylated at Tyr246.
• Immunogen DescriptionA synthesized peptide derived from human DMAP1 around the phosphorylation site of Tyr246.
• Alternative Names    DNA methyltransferase 1-associated protein 1; DNMAP1; DNMT1-associated protein 1; KIAA1425
• UniprotQ9NPF5
• Gene ID55929
• SDS-PAGE MW 53kDa
• Concentration 1 mg/ml
• Formulation Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl,0.02% sodium azide and 50% glycerol.
• Storage Store at --20˚C/1 year

• Western Blot: 1/500 - 1/2000

Involved in transcription repression and activation. Its interaction with HDAC2 may provide a mechanism for histone deacetylation in heterochromatin following replication of DNA at late firing origins. Can also repress transcription independently of histone deacetylase activity. May specifically potentiate DAXX-mediated repression of glucocorticoid receptor-dependent transcription.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting