• Product NameCAPS1 Antibody
• Host SpeciesRabbit
• ClonalityPolyclonal
• PurificationAffinity chromatography purified via peptide column
• ApplicationsELISA WB IHC
• Species ReactivityHu Ms Rt
• SpecificityNumerous isoforms of CAPS1 are known to exist. This CAPS1 antibody is predicted to be specific to CAPS1 and not recognize CAPS2.
• Immunogen TypePeptide
• Immunogen DescriptionRaised against a 21 amino acid peptide near the amino terminus of the human CAPS1.
• Target NameCAPS1
• Alternative Names    Calcium-dependent secretion activator 1, CADPS1
• Accession No. Swiss-Prot:Q9ULU8
  Gene ID:8618
• UniprotQ9ULU8
• Gene ID8618;
• Concentration 1mg/ml
• Formulation Supplied in PBS containing 0.02% sodium azide.
• Storage Can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

CAPS1 and its related protein CAPS2 encode novel neural/endocrine-specific cytosolic and peripheral membrane proteins. Both are essential components of the synaptic vesicle priming machinery and are required for the Ca2+-regulated exocytosis of secretory vesicles; CAPS-deficienct neurons contain no or very few fusion competent synaptic vesicles, causing a selective impairment of fast phasic transmitter release. CAPS1 acts at a stage in exocytosis that follows ATP-dependent priming, which involves the essential synthesis of phosphatidylinositol 4, 5-bisphosphate and is thought to be a specific regulator of large dense-core vesicle fusion.

• Western blot analysis of CAPS1 in rat brain tissue lysate with CAPS1 antibody at (A) 0.25 and (B) 0.5 ug/mL.
• Immunohistochemistry of CAPS1 in human brain with CAPS1 antibody at 5 ug/mL.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting