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GSK3α/β(Phospho-Tyr279/216) Antibody #11301

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Catalog No. Package Size Price Quantity
50ul $189.00
100ul $279.00
Availability:Yes
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Description
  • Product NameGSK3α/β(Phospho-Tyr279/216) Antibody
  • Host SpeciesRabbit
  • ClonalityPolyclonal
  • PurificationAntibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
  • ApplicationsWB IHC IF
  • Species ReactivityHu Ms Rt
  • SpecificityThe antibody detects endogenous level of GSK3α/β only when phosphorylated at tyrosine 279/216.
  • Immunogen TypePeptide-KLH
  • Immunogen DescriptionPeptide sequence around phosphorylation site of tyrosine 279/216 (V-S-Y(p)-I-C) derived from Human GSK3α/β.
  • Target NameGSK3α/β
  • ModificationPhospho
  • Alternative Names    Factor A; GSK-3 alpha/beta; kinase GSK3-alpha/beta
  • Uniprot P49840
  • Gene ID 2931;
  • Accession No. Swiss-Prot:P49840
    Gene ID:2931
  • Concentration 1.0mg/ml
  • Formulation Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
Application Details
Background

Published Papers

Herpes Simplex Virus type-1 infection induces synaptic dysfunction in cultured cortical neurons via GSK-3 activation and intraneuronal amyloid-β protein accumulation.In Sci Rep on 2015 Oct 21 by Roberto Piacentini, Domenica Donatella Li Puma et al ..PMID:26487282, , (2015),
PMID: 26487282
Phosphoproteome analysis reveals an important role for glycogen synthase kinase-3 in perfluorododecanoic acid-induced rat liver toxicity. In Toxicol Lett on 2013 Mar 27 by Hongxia Zhang, Junjie Hou, et al..PMID: 23353032, , (2013),
PMID: 23353032
Activation of GSK3β by Sirt2 is required for early lineage commitment of mouse embryonic stem cell. In PLoS One on 2013 Oct 18 by Xiaoxing Si, Wen Chen, et al..PMID: 24204656, , (2013),
PMID: 24204656
Song Chen, Ai-ran Liu, Feng-mao An Amelioration of neurodegenerative changes in cellular and rat models of diabetes-related Alzheimer¡¯s disease by exendin-4, AGE, 34(5):1211¨C1224 (2012),
PMID: 21901364
View All Published Papers Amelioration of neurodegenerative changes in cellular and rat models of diabetes-related Alzheimer's disease by exendin-4. In Age (Dordr) on 2012 Oct by Song Chen, Ai-ran Liu, et al..PMID:21901364, , (2012),
PMID: 21901364
Hirakawa Hiroshi, Nakayama Toshiyuki, Shibata Kenichiro Association of cellular localization of glycogen synthase kinase 3beta in the digestive tract with cancer development., Oncology Reports, 22(3), 481-485 (2009),
PMID: 19639192
Please let us know if you have published research using #11301 so that we can cite your reference.

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Application

WBWestern Blotting

IHCImmunohistochemistry

IFImmunofluorescence

ICCImmunocytochemistry

FCFlow Cytometry

IPImmunoprecipitation

EELISA

DBDot Blotting

ChIPChromatin Immunoprecipitation

GICAGold Immunochromatography Assay

NCNegative Control

Species Reactivity

HuHuman

MsMouse 

RtRat 

Dm Drosophila melanogaster

C Caenorhabditis elegans

MkMonkey

RbRabbit

B Bovine 

D Dog

PPig

HmHamster

ChHm Chinese Hamster 

ChkChicken  

ShpSheep