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TrkB(Phospho-Tyr706) Antibody

11328
Review: comment rank 5 pdf
  Catalog No. Package Size Price
11328-1 50ul $189.00
11328-2 100ul $279.00

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Description
  • Product Name TrkB(Phospho-Tyr706) Antibody
  • Host Species Rabbit
  • Clonality Polyclonal
  • Purification Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
  • Applications WB
  • Species Reactivity Hu Ms Rt
  • Specificity The antibody detects endogenous level of TrkB only when phosphorylated at tyrosine 706.
  • Immunogen Type Peptide-KLH
  • Immunogen Description Peptide sequence around phosphorylation site of tyrosine 706 (T-D-Y P-Y-R) derived from Human TrkB.
  • Target Name TrkB
  • Modification Phospho
  • Alternative Names BDNF/NT-3 growth factors receptor precursor; EC 2.7.10.1; GP145-TrkB; GP145-TrkB/GP95-TrkB; NTRK2
  • Accession No. Swiss-Prot: Q16620
    NCBI Protein: NP _001007098.1
  • Concentration 1.0mg/ml
  • Formulation Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
Application Details

Predicted MW: 140kd
Western blotting: 1:500~1:1000

Images
  • TrkB(Phospho-Tyr706) Antibody - SAB | Signalway Antibody

    Western blot analysis of extracts from mouse brain tissue using TrkB(Phospho-Tyr706) Antibody #11328 and the same antibody preincubated with blocking peptide.

Background

Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3 and neurotrophin-4/5 but not nerve growth factor (NGF). Involved in the development and/or maintenance of the nervous system. This is a tyrosine-protein kinase receptor. Known substrates for the TRK receptors are SHC1, PI-3 kinase, and PLC-gamma-1.

Woronowicz A, et al. Glycobiology. 2007 Jan;17(1):10-24.
Mojsilovic-Petrovic J, et al. J Neurosci. 2006 Sep 6;26(36):9250-63.
Lewis MA, et al. Mol Pharmacol. 2006 Apr;69(4):1396-404.
Cai D, et al. Physiol Genomics. 2006 Feb 14;24(3):191-7.

  • Rachel A. Hill, Yee-Wen Candace Wu, Andrea Gogos et al,Sex-denpendent alterations in BDNF-TrkB signaling in the hippocampus of reelin heterozygous mice: a role for sex steriod hormones., Neurochem., 126:389--399 (2013),
    PMID: 23414458
  • R. A. Hill, Y. W. C. Wu, P. Kwek et al,Modulatory Effects of Sex Steroid Hormones on Brain-Derived Neurotrophic Factor-Tyrosine Kinase B Expression during Adolescent Development in C57Bl/6 Mice, Journal of Neuroendocrinology, 24, 774¨C788 (2012),
    PMID: 22221196
  • Rachel A. Hill, Maarten van den Buuse et al,Sex-dependent and region-specific changes in TrkB signaling in BDNF heterozygous mice., Brain Research, 1384:51-60 (2011),
    PMID: 21281620
  • Please let us know if you have published research using #11328 so that we can cite your reference.
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    Protocol
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    Note
      Application:
    • WBWestern Blotting
    • IHCImmunohistochemistry
    • IFImmunofluorescence
    • ICCImmunocytochemistry
    • FCFlow Cytometry
    • IPImmunoprecipitation
    • EELISA
    • DBDot Blotting
    • ChIPChromatin Immunoprecipitation
    • GICAGold Immunochromatography Assay
    • NCNegative Control
      Species Reactivity:
    • HuHuman
    • MsMouse 
    • RtRat 
    • Dm Drosophila melanogaster
    • C Caenorhabditis elegans
    • MkMonkey
    • RbRabbit
    • B Bovine 
    • D Dog
    • PPig
    • HmHamster
    • ChHm Chinese Hamster 
    • ChkChicken  
    • ShpSheep  
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