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TrkB(Phospho-Tyr706) Antibody #11328

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Catalog No. Package Size Price Quantity
50ul $189.00
100ul $279.00
Availability:Yes
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Description
  • Product NameTrkB(Phospho-Tyr706) Antibody
  • Host SpeciesRabbit
  • ClonalityPolyclonal
  • PurificationAntibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
  • ApplicationsWB
  • Species ReactivityHu Ms Rt
  • SpecificityThe antibody detects endogenous level of TrkB only when phosphorylated at tyrosine 706.
  • Immunogen TypePeptide-KLH
  • Immunogen DescriptionPeptide sequence around phosphorylation site of tyrosine 706 (T-D-Y P-Y-R) derived from Human TrkB.
  • Target NameTrkB
  • ModificationPhospho
  • Alternative Names    BDNF/NT-3 growth factors receptor precursor; EC 2.7.10.1; GP145-TrkB; GP145-TrkB/GP95-TrkB; NTRK2
  • Accession No. Swiss-Prot: Q16620
    NCBI Protein: NP _001007098.1
  • Concentration 1.0mg/ml
  • Formulation Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
Application Details
Background

Published Papers

Altered Trek-1 Function in Sortilin Deficient Mice Results in Decreased Depressive-Like Behavior .In Front Pharmacol. On 2018 Aug 6 by Moreno S, Devader CM et al..PMID:30127743, , (2018),
PMID: 30127743
Sex-Dependent Effects of Environmental Enrichment on Spatial Memory and Brain-Derived Neurotrophic Factor (BDNF) Signaling in a Developmental Two-Hit Mouse Model Combining BDNF Haploinsufficiency and Chronic Glucocorticoid Stimulation.In Front Behav Neurosci On 2018 Oct 9 by Adrienne M. Grech, Udani Ratnayake et al..PMID: 30356704, , (2018),
PMID: 30356704
Chronic Intermittent Hypobaric Hypoxia Pretreatment Ameliorates Ischemia-Induced Cognitive Dysfunction Through Activation of ERK1/2-CREB-BDNF Pathway in Anesthetized Mice.In Neurochem Res on 2017 Feb by Jintian Wang , Shixiao Zhang,et al..PMID: 27822668, , (2017),
PMID: 27822668
ERα Signaling Is Required for TrkB-Mediated Hippocampal Neuroprotection in Female Neonatal Mice after Hypoxic Ischemic Encephalopathy. In eNeuro on 2016 Jan 28 by Ulas Cikla, Vishal Chanana, et al..PMID: 26839918, , (2016),
PMID: 26839918
View All Published Papers A small molecule TrkB/TrkC neurotrophin receptor co-activator with distinctive effects on neuronal survival and process outgrowth. In Neuropharmacology on 2016 Nov by Tao Yang, Stephen M Massa,et al..PMID:27334657, , (2016),
PMID: 27334657
Brain-derived neurotrophic factor heterozygous mutant rats show selective cognitive changes and vulnerability to chronic corticosterone treatment. In Neuroscience on 2015 Jan 22 by A Gururajan, R A Hill,et al..PMID:25445195, , (2015),
PMID: 25445195
High stress hormone levels accelerate the onset of memory deficits in male Huntington's disease mice. In Neurobiol Dis on 2014 Sep by Christina Mo, Terence Y Pang,et al..PMID:24825316, , (2014),
PMID: 24825316
Long-term effects of combined neonatal and adolescent stress on brain-derived neurotrophic factor and dopamine receptor expression in the rat forebrain.In Biochim Biophys Acta on 2014 Nov by Rachel A Hill, Szerenke Kiss Von Soly ,et al..PMID:25159716, , (2014),
PMID: 25159716
Sex‐specific disruptions in spatial memory and anhedonia in a “two hit” rat model correspond with alterations in hippocampal brain‐derived neurotrophic factor expression and signaling. In Hippocampus on 2014 Oct by Rachel A Hill, Maren Klug,et al..PMID:24802968, , (2014),
PMID: 24802968
Rachel A. Hill, Yee-Wen Candace Wu, Andrea Gogos Sex-denpendent alterations in BDNF-TrkB signaling in the hippocampus of reelin heterozygous mice: a role for sex steriod hormones., Neurochem., 126:389--399 (2013),
PMID: 23414458
Sex‐dependent alterations in BDNF‐TrkB signaling in the hippocampus of reelin heterozygous mice: a role for sex steroid hormones.In J Neurochem on 2013 Aug by Rachel A Hill, Yee-Wen Candace Wu, et al..PMID:23414458, , (2013),
PMID: 23414458
A small molecule TrkB ligand reduces motor impairment and neuropathology in R6/2 and BACHD mouse models of Huntington's disease. In J Neurosci on 2013 Nov 27 by Tao Yang, Christina Condon, et al..PMID: 24285878, , (2013),
PMID: 24285878
R. A. Hill, Y. W. C. Wu, P. Kwek Modulatory Effects of Sex Steroid Hormones on Brain-Derived Neurotrophic Factor-Tyrosine Kinase B Expression during Adolescent Development in C57Bl/6 Mice, Journal of Neuroendocrinology, 24, 774¨C788 (2012),
PMID: 22221196
Sex-specific and region-specific changes in BDNF–TrkB signalling in the hippocampus of 5-HT1A receptor and BDNF single and double mutant mice. In Brain Res on 2012 May 3 by YeeWen Candace Wu, Rachel A Hill, et al..PMID:22464183, , (2012),
PMID: 22464183
Rachel A. Hill, Maarten van den Buuse Sex-dependent and region-specific changes in TrkB signaling in BDNF heterozygous mice., Brain Research, 1384:51-60 (2011),
PMID: 21281620
Sex-dependent and region-specific changes in TrkB signaling in BDNF heterozygous mice. In Brain Res on 2011 Apr 12 by Rachel A Hill, Maarten van den Buuse, et al..PMID: 21281620, , (2011),
PMID: 21281620
Please let us know if you have published research using #11328 so that we can cite your reference.

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Application

WBWestern Blotting

IHCImmunohistochemistry

IFImmunofluorescence

ICCImmunocytochemistry

FCFlow Cytometry

IPImmunoprecipitation

EELISA

DBDot Blotting

ChIPChromatin Immunoprecipitation

GICAGold Immunochromatography Assay

NCNegative Control

Species Reactivity

HuHuman

MsMouse 

RtRat 

Dm Drosophila melanogaster

C Caenorhabditis elegans

MkMonkey

RbRabbit

B Bovine 

D Dog

PPig

HmHamster

ChHm Chinese Hamster 

ChkChicken  

ShpSheep