• Product NameNALP6 Antibody
• Host SpeciesRabbit
• ClonalityPolyclonal
• PurificationAffinity chromatography purified via peptide column
• ApplicationsELISA WB ICC
• Species ReactivityHu
• Immunogen TypePeptide
• Immunogen DescriptionRaised against a 16 amino acid peptide near the amino terminus of human NALP6.
• Target NameNALP6
• Alternative Names    NLR family pyrin domain containing 6, NLRP6, PYRIN-containing APAF1-like protein 5, PYPAF5, CLR11.4, PAN3
• Accession No. Swiss-Prot:P59044
  Gene ID:171389
• UniprotP59044
• Gene ID171389;
• Concentration 1mg/ml
• Formulation Supplied in PBS containing 0.02% sodium azide.
• Storage Can be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

NALP proteins include the apoptosis regulator APAF1 (apoptotic protease activating factor 1) and mammalian NOD-LRR proteins and are thought to be involved in inflammation and reproduction. NALP6, also known as PYPAF5, is highly expressed in granulocytes and T cells and co-localizes with the PYRIN-CARD protein ASC. Co-expression of NALP6 with ASC results in a synergistic activation of NF-κB and activated caspase-1-dependent cytokine processing, suggesting that NALP6 functions in immune cells to coordinate the transduction of pro-inflammatory signals.

• Western blot analysis of NALP5 in mouse brain tissue lysate with NALP5 antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide.
• Immunofluorescence of NALP6 in human brain tissue with NALP6 antibody at 20 ug/mL.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting