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MyD88 Monoclonal Antibody

26020
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  Catalog No. Package Size Price
26020 100ul $390.00

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Description
  • Product Name MyD88 Monoclonal Antibody
  • Host Species Mouse
  • Clonality Monoclonal
  • Clone No. mAb (Clone 2E9C2)
  • Purification Immunoaffinity chromotography purified IgG
  • Applications ELISA WB IHC
  • Species Reactivity Hu Ms
  • Immunogen Type Recombinant Protein
  • Immunogen Description Raised against a recombinant protein corresponding to amino acids 176 to 280 of human MyD88.
  • Target Name MyD88
  • Alternative Names MyD88 (2E9C2): Myeloid differentiation primary response gene 88
  • Accession No. AAC50954
  • Concentration 1mg/ml
  • Formulation Supplied in PBS containing 0.02% sodium azide.
  • Storage Can be stored at -20˚C, stable for one year.
Images
  • MyD88 Monoclonal Antibody - SAB | Signalway Antibody

    Western blot analysis of MyD88 in EL4 whole cell lysate with MyD88 antibody at 2 ug/mL.

Background

The pro-inflammatory cytokine IL-1 induced cellular response requires IL-1 receptor complex including IL-1RI and IL-1RAcP. MyD88 has been identified as an adapter molecule in the IL-1 signaling pathway. MyD88 associates with and recruits IRAK to the IL-1 receptor complex in response to IL-1 treatment and dominant negative form of MyD88 attenuates IL-1R-mediated NF-κB activation. MyD88 is also employed as a regulator molecule by IL-18 receptor and human Toll receptor, which are members in the Toll/IL-1R family of receptors. Targeted disruption of the MyD88 gene results in lose of cellular responses to IL-1 and IL-18, and MyD88-deficient mice lack responses to bacterial product LPS that employs Toll-like receptors 2 and 4 (TLR2 and TLR4) as the signaling receptors. MyD88 is a general adapter protein for the Toll/IL-1R family of receptors and plays an important role in the inflammatory response induced by cytokines IL-1 and IL-18 and endotoxin. MyD88 gene is expressed in many tissues.

    Please let us know if you have published research using #26020 so that we can cite your reference.
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    Protocol
    Browsing historyclear
    Note
      Application:
    • WBWestern Blotting
    • IHCImmunohistochemistry
    • IFImmunofluorescence
    • ICCImmunocytochemistry
    • FCFlow Cytometry
    • IPImmunoprecipitation
    • EELISA
    • DBDot Blotting
    • ChIPChromatin Immunoprecipitation
    • GICAGold Immunochromatography Assay
    • NCNegative Control
      Species Reactivity:
    • HuHuman
    • MsMouse 
    • RtRat 
    • Dm Drosophila melanogaster
    • C Caenorhabditis elegans
    • MkMonkey
    • RbRabbit
    • B Bovine 
    • D Dog
    • PPig
    • HmHamster
    • ChHm Chinese Hamster 
    • ChkChicken  
    • ShpSheep  
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