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AMPKα1/AMPKα2(Phospho-Thr183/Thr172) Antibody #11183

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Catalog No. Package Size Price Quantity
50ul $219.00
100ul $319.00
Availability:Yes
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Description
  • Product NameAMPKα1/AMPKα2(Phospho-Thr183/Thr172) Antibody
  • Host SpeciesRabbit
  • ClonalityPolyclonal
  • PurificationAntibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
  • ApplicationsWB IHC
  • Species ReactivityHu Ms Rt
  • SpecificityThe antibody detects endogenous level of AMPKα1/AMPKα2 only when phosphorylated at threonine 183 or 172.
  • Immunogen TypePeptide-KLH
  • Immunogen DescriptionPeptide sequence around phosphorylation site of threonine 183(L-R-T(p)-S-C)/threonine172(L- R-T(p)-S-C) derived from Human AMPKα1/AMPKα2.
  • Target NameAMPKα1/AMPKα2
  • ModificationPhospho
  • Alternative Names    AMPK; AMPKa1; AMPK2
  • Accession No. Swiss-Prot: Q13131/P54646; NCBI Gene ID: 5562/5563; NCBI mRNA: NM_006251.5/ NM_006252.3; NCBI Protein: NP_006242.5 /NP_006243.2
  • UniprotQ13131
  • Gene ID5562;
  • SDS-PAGE MW 63
  • Concentration 1.0mg/ml
  • Formulation Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage Store at -20°C
Application Details
Background

Published Papers

OR2H2 Activates CAMKKβ–AMPK–Autophagy Signaling Axis and Suppresses Senescence in VK2/E6E7 CellsInPharmaceuticals (Basel)On2023 SepbyJi Min Kim, Sina Dziobaka et al..PMID:37765029, , (2023),
PMID: 37765029
The AMPK-dependent inhibition of autophagy plays a crucial role in protecting photoreceptor from photooxidative injury In J Photochem Photobiol B On2023 AugbyYu-Lin Li , Tian-Zi Zhang et al..PMID:37302163, , (2023),
PMID: 37302161
Hepatic AMPK activation in response to dynamic REDOX balance is a biomarker of exercise to improve blood glucose control. In Elife on 2022 Sep 26 by Meiling Wu, Anda Zhao, et al..PMID:36155132, , (2022),
PMID: 36155132
Hepatic AMPK signaling dynamic activation in response to REDOX balance are sentinel biomarkers of exercise and antioxidant intervention to improve blood glucose control. In Elife on 2022 Sep 26 by Meiling Wu, Anda Zhao, et al..PMID:36155132, , (2022),
PMID: 36155132
View All Published Papers Concurrent Control of the Kaposi's Sarcoma-Associated Herpesvirus Life Cycle through Chromatin Modulation and Host Hedgehog Signaling: a New Prospect for the Therapeutic Potential of Lipoxin A4.In J Virol on 2020 Apr 16 by Asha K, Balfe N,et al..PMID:32102879, , (2020),
PMID: 32102879
Gemcitabine induces apoptosis and autophagy via the AMPK/mTOR signaling pathway in pancreatic cancer cells,In Biotechnol Appl Biochem. On 2018 Sep by Zhu J, Chen Y et al..PMID: 29575133, , (2018),
PMID: 29575133
Eupatilin ameliorates dextran sulphate sodium-induced colitis in mice partly through promoting AMPK activation. In Phytomedicine. On 2018 Jul 15 by Zhou K, Cheng R et al..PMID:30097122, , (2018),
PMID: 30097122
FSTL1 as a Potential Mediator of Exercise-Induced Cardioprotection in Post-Myocardial Infarction Rats.In Sci Rep on 2016 Aug 26 by Yue Xi, Da-Wei Gong et al..PMID: 27561749, , (2016),
PMID: 27561749
Glutaredoxins concomitant with optimal ROS activate AMPK through S-glutathionylation to improve glucose metabolism in type 2 diabetes.In Free Radic Biol Med.On 2016 Dec by Dong K, Wu M et al..PMID:27743883, , (2016),
PMID: 27743883
Neuronal Ca2+ sensor-1 contributes to stress tolerance in cardiomyocytes via activation of mitochondrial detoxification pathways.In J Mol Cell Cardiol on 2016 Oct by Tomoe Y Nakamura, Shu Nakao et al..PMID:27555477, , (2016),
PMID: 27555477
MACC1 mediates acetylcholine-induced invasion and migration by human gastric cancer cells.In Oncotarget on 2016 Apr 5 by Ting Yang, Wanming He et al..PMID: 26919111 , , (2016),
PMID: 26919111
Please let us know if you have published research using #11183 so that we can cite your reference.

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Application

WBWestern Blotting

IHCImmunohistochemistry

IFImmunofluorescence

ICCImmunocytochemistry

FCFlow Cytometry

IPImmunoprecipitation

EELISA

DBDot Blotting

ChIPChromatin Immunoprecipitation

GICAGold Immunochromatography Assay

NCNegative Control

Species Reactivity

HuHuman

MsMouse 

RtRat 

Dm Drosophila melanogaster

C Caenorhabditis elegans

MkMonkey

RbRabbit

B Bovine 

D Dog

PPig

HmHamster

ChHm Chinese Hamster 

ChkChicken  

ShpSheep