• Product NameCD161 Antibody FITC Conjugated
• Host SpeciesRabbit
• ClonalityPolyclonal
• IsotypeIgG
• PurificationPurified by Protein A.
• ApplicationsFCM IF(IHC-P)
• Species ReactivityHu
• Immunogen DescriptionKLH conjugated synthetic peptide aa 175-225 225 derived from human CD161 NK11
• ConjugatesFITC
• Excitation Emission494nm 518nm
• Target NameCD161
• Alternative Names    NKR; CD161; CLEC5B; NKR-P1; NKRP1A; NKR-P1A; hNKR-P1A; Killer cell lectin-like receptor subfamily B member 1; C-type lectin domain family 5 member B; Natural killer cell surface protein P1A; KLRB1
• Accession No. Swiss-Prot#Q12918
  NCBI Gene ID3820
• UniprotQ12918
• Gene ID3820;
• Cell Localization Extracellular
• Concentration 1mg ml
• Formulation 10mM Tris Buffered Saline containing 1% BSA, 50% glycerol and 0.09% sodium azide.
• Storage Store at 4C for 12 months.

• FCM: 1:20-100
  Immunofluorescence: 1:50-200

Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1 PKB and RPS6KA1 RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Binds also to CLEC2D LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting