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PRCP Antibody

31116
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  Catalog No. Package Size Price
31116-1 50ul $189.00
31116-2 100ul $279.00

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Description
  • Product Name PRCP Antibody
  • Host Species Rabbit
  • Clonality Polyclonal
  • Applications ELISA WB IHC
  • Species Reactivity Hu
  • Specificity The antibody detects endogenous level of total PRCP protein.
  • Immunogen Type Recombinant protein
  • Immunogen Description Fusion protein corresponding to a region derived from 46-317 amino acids of human prolylcarboxypeptidase (angiotensinase C)
  • Target Name PRCP
  • Alternative Names Prolylcarboxypeptidase (angiotensinase C), PCP; HUMPCP
  • Accession No. Swiss-Prot:O43242
    Gene ID:5709
  • Formulation Supplied at 0.7mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.3, 0.05% sodium azide and 50% glycerol.
  • Storage Store at -20˚C/1 year
Application Details

Predicted MW: 56kd
ELISA: 1:1000-1:2000
Western blotting: 1:200-1:1000
Immunohistochemistry: 1:25-1:100

Images
  • PRCP Antibody - SAB | Signalway Antibody

    Gel: 10%SDS-PAGE
    Lane1: Jurkat cell lysate
    Lane2: Human fetal liver tissue lysate
    Lysates: 50 ug per lane
    Primary antibody: 1/200 dilution
    Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution
    Exposure time: 5 minutes

  • PRCP Antibody - SAB | Signalway Antibody

    The image on the left is immunohistochemistry of paraffin-embedded human tonsil tissue using 31116(PRCP Antibody) at dilution 1/20, on the right is treated with the fusion protein.

Background
The protein encoded by this gene is a lysosomal prolylcarboxypeptidase, which cleaves C-terminal amino acids linked to proline in peptides such as angiotension II, III and des-Arg9-bradykinin. The cleavage occurs at acidic pH, but the enzyme activity is retained with some substrates at neutral pH. This enzyme has been shown to be an activator of the cell matrix-associated prekallikrein. The importance of angiotension II, one of the substrates of this enzyme, in regulating blood pressure and electrolyte balance suggests that this gene may be related to essential hypertension. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
    Please let us know if you have published research using #31116 so that we can cite your reference.
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    Protocol
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    Note
      Application:
    • WBWestern Blotting
    • IHCImmunohistochemistry
    • IFImmunofluorescence
    • ICCImmunocytochemistry
    • FCFlow Cytometry
    • IPImmunoprecipitation
    • EELISA
    • DBDot Blotting
    • ChIPChromatin Immunoprecipitation
    • GICAGold Immunochromatography Assay
    • NCNegative Control
      Species Reactivity:
    • HuHuman
    • MsMouse 
    • RtRat 
    • Dm Drosophila melanogaster
    • C Caenorhabditis elegans
    • MkMonkey
    • RbRabbit
    • B Bovine 
    • D Dog
    • PPig
    • HmHamster
    • ChHm Chinese Hamster 
    • ChkChicken  
    • ShpSheep  
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