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DNA PKcs(Ab-2609) Antibody

21179
Review: comment rank 5 pdf
  Catalog No. Package Size Price
21179-1 50ul $189.00
21179-2 100ul $279.00

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Description
  • Product Name DNA PKcs(Ab-2609) Antibody
  • Host Species Rabbit
  • Clonality Polyclonal
  • Purification Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
  • Applications WB
  • Species Reactivity Hu
  • Specificity The antibody detects endogenous level of total DNA PKcs protein.
  • Immunogen Type Peptide-KLH
  • Immunogen Description Peptide sequence around aa.2607~2611 (V-E-T-Q-A) derived from Human DNA-PK.
  • Target Name DNA PKcs
  • Alternative Names DNPK1; PRKD; PRKDC; XRCC7; P460
  • Accession No. Swiss-Prot: P78527
    NCBI Protein: NP_001075109.1
  • Concentration 1.0mg/ml
  • Formulation Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
Application Details

Predicted MW: 450kd
Western blotting: 1:500~1:1000

Images
  • DNA PKcs(Ab-2609) Antibody - SAB | Signalway Antibody

    Western blot analysis of extracts from HT29 and HepG2 cells using DNA PKcs(Ab-2609) antibody #21179.

Background
The PRKDC gene encodes the catalytic subunit of a nuclear DNA-dependent serine/threonine protein kinase (DNA-PK). The second component is the autoimmune antigen Ku (MIM 152690), which is encoded by the G22P1 gene on chromosome 22q. On its own, the catalytic subunit of DNA-PK is inactive and relies on the G22P1 component to direct it to the DNA and trigger its kinase activity; PRKDC must be bound to DNA to express its catalytic properties

Chan DW, et al. (2002) Genes Dev. Sep 15; 16(18): 2333-2338
Ding Q, et al. (2003) Mol Cell Biol. Aug; 23(16): 5836-5848
Douglas P, et al. (2002) Biochem J. Nov 15; 368(Pt 1): 243-251
    Please let us know if you have published research using #21179 so that we can cite your reference.
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    Protocol
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    Note
      Application:
    • WBWestern Blotting
    • IHCImmunohistochemistry
    • IFImmunofluorescence
    • ICCImmunocytochemistry
    • FCFlow Cytometry
    • IPImmunoprecipitation
    • EELISA
    • DBDot Blotting
    • ChIPChromatin Immunoprecipitation
    • GICAGold Immunochromatography Assay
    • NCNegative Control
      Species Reactivity:
    • HuHuman
    • MsMouse 
    • RtRat 
    • Dm Drosophila melanogaster
    • C Caenorhabditis elegans
    • MkMonkey
    • RbRabbit
    • B Bovine 
    • D Dog
    • PPig
    • HmHamster
    • ChHm Chinese Hamster 
    • ChkChicken  
    • ShpSheep  
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