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Tau (Phospho-Ser202) Antibody

11723
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  Catalog No. Package Size Price
11723-1 50ul $189.00
11723-2 100ul $279.00

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Description
  • Product Name Tau (Phospho-Ser202) Antibody
  • Host Species Rabbit
  • Clonality Polyclonal
  • Purification Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
  • Applications WB
  • Species Reactivity Hu
  • Specificity The antibody detects endogenous levels of Tau only when phosphorylated at serine 202.
  • Immunogen Type Peptide-KLH
  • Immunogen Description Peptide sequence around phosphorylation site of serine 202(P-G-S(p)-P-G) derived from Human Tau.
  • Target Name Tau
  • Modification Phospho
  • Alternative Names MAPT; MTBT1; PHF-tau;
  • Accession No. Swiss-Prot#: P10636;
    NCBI Gene#: 4137;
    NCBI Protein#: NP_058519.3.
  • SDS-PAGE MW 50-80kd
  • Concentration 1.0mg/ml
  • Formulation Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage Store at -20˚C/1 year
Application Details

Western blotting: 1:500~1:1000

Images
  • Tau (Phospho-Ser202) Antibody - SAB | Signalway Antibody

    Western blot analysis of extracts from JK cells (Lane 2), using Tau (Phospho-Ser202) Antibody #11723. The lane on the left is treated with antigen-specific peptide.

Background

Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.

Goedert M., Proc. Natl. Acad. Sci. U.S.A. 85:4051-4055(1988).
Goedert M., EMBO J. 8:393-399(1989).
Lee G., Neuron 2:1615-1624(1989).

    Please let us know if you have published research using #11723 so that we can cite your reference.
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    Protocol
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    Note
      Application:
    • WBWestern Blotting
    • IHCImmunohistochemistry
    • IFImmunofluorescence
    • ICCImmunocytochemistry
    • FCFlow Cytometry
    • IPImmunoprecipitation
    • EELISA
    • DBDot Blotting
    • ChIPChromatin Immunoprecipitation
    • GICAGold Immunochromatography Assay
    • NCNegative Control
      Species Reactivity:
    • HuHuman
    • MsMouse 
    • RtRat 
    • Dm Drosophila melanogaster
    • C Caenorhabditis elegans
    • MkMonkey
    • RbRabbit
    • B Bovine 
    • D Dog
    • PPig
    • HmHamster
    • ChHm Chinese Hamster 
    • ChkChicken  
    • ShpSheep  
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