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GRIN2B (Phospho-Ser1303) Antibody

11821
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  Catalog No. Package Size Price
11821-1 50ul $189.00
11821-2 100ul $279.00

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Description
  • Product Name GRIN2B (Phospho-Ser1303) Antibody
  • Host Species Rabbit
  • Clonality Polyclonal
  • Purification Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
  • Applications WB
  • Species Reactivity Hu Ms Rt
  • Specificity The antibody detects endogenous levels of GRIN2B only when phosphorylated at serine 1303.
  • Immunogen Type Peptide-KLH
  • Immunogen Description Peptide sequence around phosphorylation site of Serine 1303(Q-H-S(p)-Y-D) derived from Human GRIN2B.
  • Target Name GRIN2B
  • Modification Phospho
  • Alternative Names GRIN2B; NMDE2; NME2; NR2B; NR3
  • Accession No. Swiss-Prot#: Q13224;
    NCBI Gene#: 2904;
    NCBI Protein#: NP_000825.2.
  • SDS-PAGE MW 170kd
  • Concentration 1.0mg/ml
  • Formulation Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage Store at -20˚C/1 year
Application Details

Western blotting: 1:500~1:1000

Images
  • GRIN2B (Phospho-Ser1303) Antibody - SAB | Signalway Antibody

    Western blot analysis of extracts from Mouse brain cells using GRIN2B (Phospho-Ser1303) Antibody #11821.The lane on the right is treated with the antigen-specific peptide.

Background

N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of three different subunits: NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The NR2 subunit acts as the agonist binding site for glutamate. This receptor is the predominant excitatory neurotransmitter receptor in the mammalian brain.

Adams S.L., Biochim. Biophys. Acta 1260:105-108(1995).
Hess S.D., J. Pharmacol. Exp. Ther. 278:808-816(1996).
Mandich P., Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases.

    Please let us know if you have published research using #11821 so that we can cite your reference.
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    Protocol
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    Note
      Application:
    • WBWestern Blotting
    • IHCImmunohistochemistry
    • IFImmunofluorescence
    • ICCImmunocytochemistry
    • FCFlow Cytometry
    • IPImmunoprecipitation
    • EELISA
    • DBDot Blotting
    • ChIPChromatin Immunoprecipitation
    • GICAGold Immunochromatography Assay
    • NCNegative Control
      Species Reactivity:
    • HuHuman
    • MsMouse 
    • RtRat 
    • Dm Drosophila melanogaster
    • C Caenorhabditis elegans
    • MkMonkey
    • RbRabbit
    • B Bovine 
    • D Dog
    • PPig
    • HmHamster
    • ChHm Chinese Hamster 
    • ChkChicken  
    • ShpSheep  
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