• Product NameDC-SIGN Polyclonal Antibody Cy7 Conjugated
• Host SpeciesRabbit
• ClonalityPolyclonal
• IsotypeIgG
• PurificationPurified by Protein A.
• ApplicationsIF;FC
• Species ReactivityHu
• Immunogen DescriptionKLH conjugated synthetic peptide derived from human DC-SIGN CD209
• ConjugatesCy7
• Excitation Emission743nm 767nm
• Target NameDC-SIGN
• Alternative Names    CLEC4L; Dendritic cell-specic ICAM-3-grabbing non-integrin 1; C type lectin domain family 4 member L; CD 209; CD209; CD209 antigen; CD209 antigen-like protein A; CD209 molecule; Cd209a; CDSIGN; CIRE; DC SIGN1; DCSIGN; Dendritic cell specic ICAM 3 grabbing nonintegrin 1; Dendritic cell specic ICAM3 g
• Accession No. NCBI Gene ID:30835
• UniprotQ9NNX6
• Gene ID30835;
• Cell Localization Extracellular
• Concentration 1mg ml
• Formulation Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide.
• Storage Store at 4C for 12 months.

• IF:1:50-200

Dendritic cells (DCs) that control immune responses were recently found to capture and transport HIV from the mucosal area to remote lymph nodes, where DCs hand over HIV to CD4+ T lymphocytes. DCs also amplify the amount of virus and extend the duration of viral infectivity. Multiple strains of HIV1, HIV2 and SIV bind to DCs via DCSIGN. ICAM3 is the natural ligand for DC-SIGN. A DC-SIGN homologue (termed CD299, DC-SIGNR, L-SIGN and DCSIGN2) was identified recently. DC-SIGN forms a novel gene family with DC-SIGNR and many alternatively spliced isoforms of DC-SIGN and DC-SIGNR. The expression of DC-SIGN was found in mucosal tissues including placenta, small intestine, and rectum.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting