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GANP Antibody

33383
Review: comment rank 5 pdf
  Catalog No. Package Size Price
33383-1 50ul $189.00
33383-2 100ul $279.00

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Description
  • Product Name GANP Antibody
  • Host Species Rabbit
  • Clonality Polyclonal
  • Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Applications WB IHC IF
  • Species Reactivity Hu Ms
  • Specificity The antibody detects endogenous levels of total GANP protein.
  • Immunogen Type Peptide
  • Immunogen Description Synthesized peptide derived from human GANP.
  • Target Name GANP
  • Alternative Names 80 kda MCM3-associated protein; GANP protein; KIAA0572; MAP80; MCM3A
  • Accession No. Swiss-Prot: O60318
    NCBI Gene ID: 8888
  • SDS-PAGE MW 218kd
  • Concentration 1.0mg/ml
  • Formulation Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage Store at -20˚C
Application Details

Western blotting: 1:500~1:3000
Immunohistochemistry: 1:50~1:100

Images
  • GANP Antibody - SAB | Signalway Antibody

    Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using GANP antibody #33383.

  • GANP Antibody - SAB | Signalway Antibody

    Western blot analysis of extracts from NIH/3T3 cells, using GANP antibody #33383.

  • GANP Antibody - SAB | Signalway Antibody

    Western blot analysis of extracts from HepG2 cells (Lane 2) and A549 cells (Lane 3), using GANP antiobdy #33383. The lane on the left is treated with synthesized peptide.

Background
Isoform GANP:Essential for the generation of high-affinity B-cells against T-cell-dependent antigens by affecting somatic hypermutation at the IgV-regions. May have stimulation-dependent DNA primase activity that would generate extra RNA primers in very rapidely proliferating cells and would support clonal expansion of differentiating B-cells By similarity. Involved in the nuclear export of poly(A)-containing mRNAs by acting as a scaffold for the TREX-2 complex. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. Isoform MCM3AP:Acetyltransferase targeting MCM3. Inhibits initiation of DNA replication, but not elongation.

Nobuo Sakaguchi, J. Immunol., Apr 2005; 174: 4485 - 4494.
Kazuhiko Kuwahara, Blood, Apr 2000; 95: 2321 - 2328.
Y Kono, K Maeda, Genes Cells, Aug 2002; 7: 821 - 834.
Kazuhiko Kuwahara, PNAS, Aug 2001; 98: 10279.
    Please let us know if you have published research using #33383 so that we can cite your reference.
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    Protocol
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    Note
      Application:
    • WBWestern Blotting
    • IHCImmunohistochemistry
    • IFImmunofluorescence
    • ICCImmunocytochemistry
    • FCFlow Cytometry
    • IPImmunoprecipitation
    • EELISA
    • DBDot Blotting
    • ChIPChromatin Immunoprecipitation
    • GICAGold Immunochromatography Assay
    • NCNegative Control
      Species Reactivity:
    • HuHuman
    • MsMouse 
    • RtRat 
    • Dm Drosophila melanogaster
    • C Caenorhabditis elegans
    • MkMonkey
    • RbRabbit
    • B Bovine 
    • D Dog
    • PPig
    • HmHamster
    • ChHm Chinese Hamster 
    • ChkChicken  
    • ShpSheep  
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