Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity.
Diana L. Mandelker, Cancer Res., Jun 2005; 65: 4963 - 4968.
Taiji Yamazaki, Clin. Cancer Res., Jan 2002; 8: 192.
Ekmel Tezel, Clin. Cancer Res., Dec 2000; 6: 4764.
Kenji Hibi, Am. J. Pathol., Sep 1999; 155: 711.