• Product NameSodium Channel-pan Antibody
• Host SpeciesRabbit
• ClonalityPolyclonal
• PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• ApplicationsWB IHC
• Species ReactivityHu Ms Rt
• SpecificityThe antibody detects endogenous levels of total sodium channel protein.
• Immunogen TypePeptide
• Immunogen DescriptionSynthesized peptide derived from human sodium channel.
• Target NameSodium Channel-pan
• Alternative Names    CIN5; HH1; SCN5A; Sodium channel protein; cardiac muscle alpha-subunit
• Accession No. Swiss-Prot: Q14524
  NCBI Gene ID: 6323/6326/6328/6329/6331/6334/6335/6336/11280
• UniprotQ14524
• Gene ID6331;
• SDS-PAGE MW 230kd
• Concentration 1.0mg/ml
• Formulation Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Storage Store at -20˚C

• Western blotting: 1:500~1:3000
  Immunohistochemistry: 1:50~1:100
  

This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant Na+ channel isoform. This channel is responsible for the initial upstroke of the action potential. Channel inactivation is regulated by intracellular calcium levels.

Sebastian K.G. Maier, Circulation, Mar 2004; 109: 1421 - 1427.
T.R. Cummins, Neurology, Jan 2003; 60: 224 - 229.
Christopher A. Ahern, Circ. Res., May 2005; 96: 991 - 998.
Jyoti Dhar Malhotra, Circulation, Mar 2001; 103: 1303 - 1310.

• Western blot analysis of extracts from HuvEc cells, using Sodium Channel-pan antibody #33488.
• Immunohistochemical analysis of paraffin-embedded human heart tissue using Sodium Channel-pan antibody #33488.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting