• Product NameSynuclein-pan Antibody
• Host SpeciesRabbit
• ClonalityPolyclonal
• PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• ApplicationsWB IHC
• Species ReactivityHu Ms Rt
• SpecificityThe antibody detects endogenous levels of total Synuclein protein.
• Immunogen TypePeptide
• Immunogen DescriptionSynthesized peptide derived from human synuclein.
• Target NameSynuclein-pan
• Alternative Names    NACP; Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; SYN; SYUA
• Accession No. Swiss-Prot: P37840
  NCBI Gene ID: 6622
• UniprotP37840
• Gene ID6622;
• SDS-PAGE MW 14kd
• Concentration 1.0mg/ml
• Formulation Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Storage Store at -20˚C

• Western blotting: 1:500~1:3000
  Immunohistochemistry: 1:50~1:100
  

May be involved in the regulation of dopamine release and transport. Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation.

Eirene Kontopoulos, Hum. Mol. Genet., Oct 2006; 15: 3012 - 3023.
Heather Snyder, J. Biol. Chem., Mar 2005; 280: 7562 - 7569.
Wanli W. Smith, J. Neurosci., Jun 2005; 25: 5544 - 5552.
Yuxin Fan, Hum. Mol. Genet., Oct 2006; 15: 3002 - 3011.

• Western blot analysis of extracts from rat heart, using Synuclein-pan antibody #33495.
• Immunohistochemical analysis of paraffin-embedded human brain tissue using Synuclein-pan antibody #33495.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting