Functions as guanine nucleotide exchange factor that activates RAC1. May have relatively low activity. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion By similarity.
Nagase T., DNA Res. 5:31-39(1998).
The MGC Project Team, Genome Res. 14:2121-2127(2004).
Jandrig B., Oncogene 23:9295-9302(2004).