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FIR Antibody

33622
Review: comment rank 5 pdf
  Catalog No. Package Size Price
33622-1 50ul $189.00
33622-2 100ul $279.00

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Description
  • Product Name FIR Antibody
  • Host Species Rabbit
  • Clonality Polyclonal
  • Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Applications WB
  • Species Reactivity Hu Ms
  • Specificity The antibody detects endogenous levels of total FIR protein.
  • Immunogen Type Peptide
  • Immunogen Description Synthesized peptide derived from Internal of human FIR.
  • Target Name FIR
  • Alternative Names FERM; RhoGEF and pleckstrin domain protein 2; FGD1-related Cdc42-GEF; FIR; FRG
  • Accession No. Swiss-Prot: O94887
    NCBI Gene ID: 9855
  • SDS-PAGE MW 119kd
  • Concentration 1.0mg/ml
  • Formulation Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage Store at -20˚C
Application Details

Western blotting: 1:500~1:3000

Images
  • FIR Antibody - SAB | Signalway Antibody

    Western blot analysis of extracts from HuvEc cells, using FIR antibody #33622.

Background
Functions as guanine nucleotide exchange factor that activates RAC1. May have relatively low activity. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion By similarity.

Nagase T., DNA Res. 5:31-39(1998).
The MGC Project Team, Genome Res. 14:2121-2127(2004).
Jandrig B., Oncogene 23:9295-9302(2004).
    Please let us know if you have published research using #33622 so that we can cite your reference.
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    Protocol
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    Note
      Application:
    • WBWestern Blotting
    • IHCImmunohistochemistry
    • IFImmunofluorescence
    • ICCImmunocytochemistry
    • FCFlow Cytometry
    • IPImmunoprecipitation
    • EELISA
    • DBDot Blotting
    • ChIPChromatin Immunoprecipitation
    • GICAGold Immunochromatography Assay
    • NCNegative Control
      Species Reactivity:
    • HuHuman
    • MsMouse 
    • RtRat 
    • Dm Drosophila melanogaster
    • C Caenorhabditis elegans
    • MkMonkey
    • RbRabbit
    • B Bovine 
    • D Dog
    • PPig
    • HmHamster
    • ChHm Chinese Hamster 
    • ChkChicken  
    • ShpSheep  
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