• Product NameITPKB Antibody
• Host SpeciesRabbit
• ClonalityPolyclonal
• PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• ApplicationsWB
• Species ReactivityHu Ms Rt
• SpecificityThe antibody detects endogenous levels of total ITPKB protein.
• Immunogen TypePeptide
• Immunogen DescriptionSynthesized peptide derived from Internal of human ITPKB.
• Target NameITPKB
• Alternative Names    Inositol 1; 4; 5-trisphosphate 3-kinase B; Inositol-trisphosphate 3-kinase B; InsP 3-kinase B
• Accession No. Swiss-Prot: P27987
  NCBI Gene ID: 3707
• UniprotP27987
• Gene ID3707;
• SDS-PAGE MW 102kd
• Concentration 1.0mg/ml
• Formulation Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Storage Store at -20˚C

• Western blotting: 1:500~1:3000
  
  

The protein encoded by this protein regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of this encoded protein is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity.

Dewaste V., Biochem. Biophys. Res. Commun. 291:400-405(2002).
Bertsch U., Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases.
Gregory S.G., Nature 441:315-321(2006).

• Western blot analysis of extracts from Jurkat cells, using ITPKB antibody #33734.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting