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CIITA Antibody

33753
Review: comment rank 5 pdf
  Catalog No. Package Size Price
33753-1 50ul $189.00
33753-2 100ul $279.00

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Description
  • Product Name CIITA Antibody
  • Host Species Rabbit
  • Clonality Polyclonal
  • Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Applications WB
  • Species Reactivity Hu Ms Rt
  • Specificity The antibody detects endogenous levels of total CIITA protein.
  • Immunogen Type Peptide
  • Immunogen Description Synthesized peptide derived from internal of human CIITA.
  • Target Name CIITA
  • Alternative Names MHC class II transactivator; CIITA; CIITA; MHC2TA;
  • Accession No. Swiss-Prot: P33076
    NCBI Gene ID: 4261
  • SDS-PAGE MW 123kd
  • Concentration 1.0mg/ml
  • Formulation Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage Store at -20˚C
Application Details

Western blotting: 1:500~1:3000

Images
  • CIITA Antibody - SAB | Signalway Antibody

    Western blot analysis of extracts from K562 cells, using CIITA antibody #33753.

Background
Essential for transcriptional activity of the HLA class II promoter; activation is via the proximal promoter. No DNA binding of in vitro translated CIITA was detected. May act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both. Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter. Also mediates enhanced MHC class I transcription; the promoter element requirements for CIITA-mediated transcription are distinct from those of constitutive MHC class I transcription, and CIITA can functionally replace TAF1 at these genes. Exhibits intrinsic GTP-stimulated acetyltransferase activity. Exhibits serine/threonine protein kinase activity: can phosphorylate the TFIID component TAF7, the RAP74 subunit of the general transcription factor TFIIF, histone H2B at 'Ser-37' and other histones (in vitro).

Steimle V., Cell 75:135-146(1993).
Al-Kandari W., J. Mol. Biol. 369:1175-1187(2007).
Al-Kandari W., Mol. Immunol. 44:311-321(2007).
Croager E.J., Biochim. Biophys. Acta 1353:231-235(1997).
    Please let us know if you have published research using #33753 so that we can cite your reference.
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    Protocol
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    Note
      Application:
    • WBWestern Blotting
    • IHCImmunohistochemistry
    • IFImmunofluorescence
    • ICCImmunocytochemistry
    • FCFlow Cytometry
    • IPImmunoprecipitation
    • EELISA
    • DBDot Blotting
    • ChIPChromatin Immunoprecipitation
    • GICAGold Immunochromatography Assay
    • NCNegative Control
      Species Reactivity:
    • HuHuman
    • MsMouse 
    • RtRat 
    • Dm Drosophila melanogaster
    • C Caenorhabditis elegans
    • MkMonkey
    • RbRabbit
    • B Bovine 
    • D Dog
    • PPig
    • HmHamster
    • ChHm Chinese Hamster 
    • ChkChicken  
    • ShpSheep  
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