Dual regulator of transcription and autophagy. Positively regulates autophagy and is required for autophagosome formation and processing. May act as a scaffold protein that recruits MAP1LC3A, GABARAP and GABARAPL2 and brings them to the autophagosome membrane by interacting with VMP1 where, in cooperation with the BECN1-PI3-kinase class III complex, they trigger autophagosome development. Acts as a transcriptional activator of THRA.
Baumgartner B.G., Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases.
Deloukas P., Nature 414:865-871(2001).
The MGC Project Team, Genome Res. 14:2121-2127(2004).