• Product NameKIAA1967 Antibody
• Host SpeciesRabbit
• ClonalityPolyclonal
• PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• ApplicationsWB
• Species ReactivityHu
• SpecificityThe antibody detects endogenous levels of total KIAA1967 protein.
• Immunogen TypePeptide
• Immunogen DescriptionSynthesized peptide derived from internal of human KIAA1967.
• Target NameKIAA1967
• Alternative Names    Protein KIAA1967; Deleted in breast cancer gene 1 protein; DBC.1; DBC-1; p30 DBC
• Accession No. Swiss-Prot: Q8N163
  NCBI Gene ID: 57805
• UniprotQ8N163
• Gene ID57805;
• SDS-PAGE MW 102kd
• Concentration 1.0mg/ml
• Formulation Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Storage Store at -20˚C

• Western blotting: 1:500~1:3000
  
  

Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis. Inhibits SUV39H1 methyltransferase activity. As part of a histone H3-specific methyltransferase complex may mediate ligand-dependent transcriptional activation by nuclear hormone receptors. Plays a critical role in maintaining genomic stability and cellular integrity following UV-induced genotoxic stress.

Nagase T., DNA Res. 8:319-327(2001).
Hamaguchi M., Proc. Natl. Acad. Sci. U.S.A. 99:13647-13652(2002).
Olsen J.V., Cell 127:635-648(2006).

• Western blot analysis of extracts from Jurkat cells, using KIAA1967 antibody #33965.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting