Spindle assembly factor. Required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules. Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation.
Manda R., Genomics 61:5-14(1999).
Zhang Y., Cytogenet. Cell Genet. 84:182-183(1999).
Wang Y., J. Immunol. 169:1102-1109(2002).