• Product NameCollagen XVIII α1 Antibody
• Host SpeciesRabbit
• ClonalityPolyclonal
• PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• ApplicationsIHC IF
• Species ReactivityHu Ms
• SpecificityThe antibody detects endogenous levels of total Collagen XVIII α1 protein.
• Immunogen TypePeptide
• Immunogen DescriptionSynthesized peptide derived from internal of human Collagen XVIII α1.
• Target NameCollagen XVIII α1
• Alternative Names    Collagen alpha-1(XVIII) chain; Endostatin; COIA1;
• Accession No. Swiss-Prot: P39060
  NCBI Gene ID: 80781
• UniprotP39060
• Gene ID80781;
• SDS-PAGE MW 178kd
• Concentration 1.0mg/ml
• Formulation Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Storage Store at -20˚C

• 
  Immunohistochemistry: 1:50~1:100
  Immunofluorescence: 1:100~1:500

COLA18A probably plays a major role in determining the retinal structure as well as in the closure of the neural tube.Endostatin potently inhibits endothelial cell proliferation and angiogenesis. May inhibit angiogenesis by binding to the heparan sulfate proteoglycans involved in growth factor signaling.

Saarela J., Matrix Biol. 16:319-328(1998).
Elamaa H., Matrix Biol. 22:427-442(2003).
Hattori M, Nature 405:311-319(2000).

• Immunohistochemistry analysis of paraffin-embedded human liver carcinoma tissue using Collagen XVIII α1 antibody #34216.
• Immunofluorescence analysis of A549 cells, using Collagen XVIII α1 antibody #34216.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting