Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell-surface expression of HRH3. Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis).
Wiemann S., Genome Res. 11:422-435(2001).
Edwards J.C.; Am. J. Physiol. 276:F398-F408(1999).
Chuang J.Z., J. Neurosci. 19:2919-2928(1999).
