• Product NameGADD45GIP1 Antibody
• Host SpeciesRabbit
• ClonalityPolyclonal
• PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• ApplicationsIHC
• Species ReactivityHu
• SpecificityThe antibody detects endogenous levels of total GADD45GIP1 protein.
• Immunogen TypePeptide
• Immunogen DescriptionSynthesized peptide derived from internal of human GADD45GIP1.
• Target NameGADD45GIP1
• Alternative Names    Growth arrest and DNA-damage-inducible proteins-interacting protein 1; CR6-interacting factor 1; CRIF1; CKII beta-associating protein; Papillomavirus L2-interacting nuclear protein 1
• Accession No. Swiss-Prot: Q8TAE8
  NCBI Gene ID: 90480
• UniprotQ8TAE8
• Gene ID90480;
• SDS-PAGE MW 25kd
• Concentration 1.0mg/ml
• Formulation Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Storage Store at -20˚C

• 
  Immunohistochemistry: 1:50~1:100
  

Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis.

Goernemann J., Virology 303:69-78(2002).
Chung H.K., J. Biol. Chem. 278:28079-28088(2003).
The MGC Project Team, Genome Res. 14:2121-2127(2004).

• Immunohistochemistry analysis of paraffin-embedded human brain tissue using GADD45GIP1 antibody #34708.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting