• Product NameMSX2 Antibody
• Host SpeciesRabbit
• ClonalityPolyclonal
• PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• ApplicationsWB
• Species ReactivityHu Ms
• SpecificityThe antibody detects endogenous levels of total MSX2protein.
• Immunogen TypePeptide
• Immunogen DescriptionSynthesized peptide derived from Internal of human MSX2.
• Target NameMSX2
• Alternative Names    CRS2; FPP; Homeobox protein Hox-8; Homeobox protein MSX-2; HOX8
• Accession No. Swiss-Prot: P35548
  NCBI Gene ID: 4488
• UniprotP35548
• Gene ID4488;
• SDS-PAGE MW 29kd
• Concentration 1.0mg/ml
• Formulation Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Storage Store at -20˚C

• Western blotting: 1:500~1:3000
  
  

Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antogonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter.

Hodgkinson J.E., Biochim. Biophys. Acta 1174:11-16(1993).
Jabs E.W., Cell 75:443-450(1993).
Iimura T., DNA Seq. 8:87-92(1997).

• Western blot analysis of extracts from COLO205 cells, using MSX2 antibody #34744.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting