Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance, e.g. towards transplants. Interferes with TNFRSF5-signaling and NF-kappa-B up-regulation. Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.
Arm J.P., J. Immunol. 159:2342-2349(1997).
Borges L., J. Immunol. 159:5192-5196(1997).
Liu W.R., Immunogenetics 51:659-669(2000).