• Product NameOAZ1 Antibody
• Host SpeciesRabbit
• ClonalityPolyclonal
• PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• ApplicationsIHC
• Species ReactivityHu Ms
• SpecificityThe antibody detects endogenous levels of total OAZ1 protein.
• Immunogen TypePeptide
• Immunogen DescriptionSynthesized peptide derived from N-terminal of human OAZ1.
• Target NameOAZ1
• Alternative Names    Ornithine decarboxylase antizyme; ODC-Az;
• Accession No. Swiss-Prot: P54368
  NCBI Gene ID: 4946
• UniprotP54368
• Gene ID4946;
• SDS-PAGE MW 25kd
• Concentration 1.0mg/ml
• Formulation Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Storage Store at -20˚C

• 
  Immunohistochemistry: 1:50~1:100
  

Binds to, and destabilizes, ornithine decarboxylase which is then degraded. Also inhibits cellular uptake of polyamines by inactivating the polyamine uptake transporter. SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1.

Tewari D.S., Biochim. Biophys. Acta 1209:293-295(1994).
Hideyama T., Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases.
Yang D., Biochem. Mol. Biol. Int. 38:957-964(1996).

• Immunohistochemistry analysis of paraffin-embedded human brain tissue using OAZ1 antibody #34883.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting