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Enzymes

STAT3(Phospho-Ser727) Antibody #11046

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Catalog No. Package Size Price Quantity
50ul $219.00
100ul $319.00
Availability:Yes
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Description
  • Product NameSTAT3(Phospho-Ser727) Antibody
  • Host SpeciesRabbit
  • ClonalityPolyclonal
  • PurificationAntibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
  • ApplicationsWB IHC IF
  • Species ReactivityHu Ms Rt
  • SpecificityThe antibody detects endogenous level of STAT3 only when phosphorylated at serine 727.
  • Immunogen TypePeptide-KLH
  • Immunogen DescriptionPeptide sequence around phosphorylation site of serine 727 (P-M-S(p)-P-R) derived from Human STAT3.
  • Target NameSTAT3
  • ModificationPhospho
  • Alternative Names    APRF, HIES
  • Accession No. Swiss-Prot: P40763
    NCBI Protein: NP_003141.2
  • UniprotP40763
  • Gene ID6774;
  • Concentration 1.0mg/ml
  • Formulation Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
Application Details
Background

Published Papers

Anti-inflammatory and metabolic reprogramming effects of MENK produce antitumor response in CT26 tumor-bearing mice.In J Leukoc Biol on 2020 Jan 29. by Tuo Y, Zhang Z, et al..PMID:31994797, , (2020),
PMID: 31994797
A thiazole-derived oridonIn analogue exhibits antitumor activity by directly and allosterically InhibitIng STAT3. In J Biol Chem on 2019 Nov 15;by Shen X, Zhao L,et al..PMID:31594861, , (2019),
PMID: 31594861
Migration Suppression of Small Cell Lung Cancer by Polysaccharides from Nostoc commune Vaucher. In J Agric Food Chem on 2016 Aug 17 by Min Guo, Guo-Bin Ding,et al..PMID: 27465400, , (2016),
PMID: 27465400
Prognostic significance of serine-phosphorylated STAT3 expression in pT1-T2 oral tongue carcinoma.In Clin Exp Otorhinolaryngol On 2015 Sep by Elena Fasanaro , Claudia Staffieri et al..PMID:26330924, , (2015),
PMID: 26330924
View All Published Papers Pwp1 Is Required for the Differentiation Potential of Mouse Embryonic Stem Cells Through Regulating Stat3 Signaling. In Stem Cells on 2015 Mar by Junwei Shen, Wenwen Jia,et al..PMID:25335925, , (2015),
PMID: 25335925
Blocking the bFGF/STAT3 interaction through specific signaling pathways induces apoptosis in glioblastoma cells.In J Neurooncol 2014 Oct by Jingchao Wu , Xuequan Feng et al..PMID: 25048528, , (2014),
PMID: 25048528
Protein Kinase CK2 Inhibition Down Modulates the NF-kB and STAT3 Survival Pathways, Enhances the Cellular Proteotoxic Stress and Synergistically Boosts the Cytotoxic Effect of Bortezomib on Multiple Myeloma and Mantle Cell Lymphoma Cells. In PLoS One on 2013 Sep 27 by Sabrina Manni, Alessandra Brancalion, et al..PMID:24086494 , , (2013),
PMID: 24086494
Neurotrophic effects of leukemia inhibitory factor on neural cells derived from human embryonic stem cells. In Stem Cells on 2012 Nov by Anirban Majumder, Saswati Banerjee, et al..PMID: 22899336 , , (2012),
PMID: 22899336
Neurotrophic effects of leukemia inhibitory factor on neural cells derived from human embryonic stem cells. In Stem Cells on 2012 Nov by Anirban Majumder, Saswati Banerjee, et al..PMID: 22899336 , , (2012),
PMID: 22899336
Induction of interleukin-10 is dependent on p38 mitogen-activated protein kinase pathway in macrophages infected with porcine reproductive and respiratory syndrome virus. In Virol J on 2012 Aug 21 by Jun Hou, Lianghai Wang, et al..PMID: 22909062, , (2012),
PMID: 22909062
Canonical notch pathway protects hepatocytes from ischemia/reperfusion injury in mice by repressing reactive oxygen species production through JAK2/STAT3 signaling.In Hepatology on 2011 Sep 2 by Yu HC, Qin HY,et al..PMID:21633967, , (2011),
PMID: 21633967
Resistance to bleomycin-induced lung fibrosis in MMP-8 deficient mice is mediated by interleukin-10. In PLoS One on 2010 Oct 7 by Emilio Garca-Prieto, Adrin Gonzlez-Lpez, et al..PMID: 20949050, , (2010),
PMID: 20949050
Significance and relationship between Cripto-1 and p-STAT3 expression in gastric cancer and precancerous lesions. In World J Gastroenterol on 2010 Feb 7 by Jian-Guo Zhang, Jing Zhao, et al..PMID: 20128024, , (2010),
PMID: 20128024
Please let us know if you have published research using #11046 so that we can cite your reference.

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Application

WBWestern Blotting

IHCImmunohistochemistry

IFImmunofluorescence

ICCImmunocytochemistry

FCFlow Cytometry

IPImmunoprecipitation

EELISA

DBDot Blotting

ChIPChromatin Immunoprecipitation

GICAGold Immunochromatography Assay

NCNegative Control

Species Reactivity

HuHuman

MsMouse 

RtRat 

Dm Drosophila melanogaster

C Caenorhabditis elegans

MkMonkey

RbRabbit

B Bovine 

D Dog

PPig

HmHamster

ChHm Chinese Hamster 

ChkChicken  

ShpSheep