• Product NameBCL7A Antibody
• Host SpeciesRabbit
• ClonalityPolyclonal
• PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• ApplicationsWB
• Species ReactivityHu
• SpecificityThe antibody detects endogenous levels of total BCL7A protein.
• Immunogen TypePeptide
• Immunogen DescriptionSynthesized peptide derived from internal of human BCL7A.
• Target NameBCL7A
• Alternative Names    B-cell CLL/lymphoma 7 family member A; B-cell CLL/lymphoma 7A; B-cell CLL/lymphoma-7; BCL7; BCL7A
• Accession No. Swiss-Prot: Q4VC05
  NCBI Gene ID: 605
• UniprotQ4VC05
• Gene ID605;
• SDS-PAGE MW 22kd
• Concentration 1.0mg/ml
• Formulation Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Storage Store at -20˚C

• Western blotting: 1:500~1:3000
  
  

This gene is directly involved, with Myc and IgH, in a three-way gene translocation in a Burkitt lymphoma cell line. As a result of the gene translocation, the N-terminal region of the gene product is disrupted, which is thought to be related to the pathogenesis of a subset of high-grade B cell non-Hodgkin lymphoma. The N-terminal segment involved in the translocation includes the region that shares a strong sequence similarity with those of BCL7B and BCL7C. Two transcript variants encoding different isoforms have been found for this gene.

Zani V.J., Blood 87:3124-3134(1996).
Ota T., Nat. Genet. 36:40-45(2004).
Matsuoka S., Science 316:1160-1166(2007).

• Western blot analysis of extracts from HuvEc cells, using BCL7A antibody #35248.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting