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CRELD2 Antibody

36370
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  Catalog No. Package Size Price
36370 100ul $279.00

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Description
  • Product Name CRELD2 Antibody
  • Host Species Rabbit
  • Clonality Polyclonal
  • Purification Antigen affinity purification.
  • Applications WB IHC
  • Species Reactivity Hu
  • Specificity The antibody detects endogenous levels of total CRELD2 protein.
  • Immunogen Type Recombinant Protein
  • Immunogen Description Fusion protein corresponding to residues near the C terminal of human cysteine-rich with EGF-like domains 2
  • Target Name CRELD2
  • Alternative Names CREL2;DKFZp667O055;MGC11256
  • Accession No. Swiss-Prot#: Q6UXH1
    NCBI Gene ID: 79174
    Gene Accssion: BC002894
  • SDS-PAGE MW 38kd
  • Concentration 2.2mg/ml
  • Formulation Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
  • Storage Store at -20˚C
Application Details

Western blotting: 1:500-1:2000
Immunohistochemistry: 1:50-1:200

Images
  • CRELD2 Antibody - SAB | Signalway Antibody

    Gel: 8%SDS-PAGE
    Lysates (from left to right): Human normal colon tissue
    Amount of lysate: 40ug per lane
    Primary antibody: 1/550 dilution
    Secondary antibody dilution: 1/8000
    Exposure time: 2 minutes

  • CRELD2 Antibody - SAB | Signalway Antibody

    Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue using #36370 at dilution 1/50.

Background
The epidermal growth factor (EGF) repeat-containing proteins constitute an expanding family of proteins that are involved in several cellular activities, such as blood coagulation, fibrinolysis, cell adhesion and neural and vertebrate development. CRELD2 (cysteine-rich with EGF-like domains 2) is a 353 amino acid protein that is ubiquitously expressed and contains two FU domains and two EGF-like domains. Localized to the endoplasmic reticulum and secreted into the cell, CRELD2 interacts with AChR?4, possibly regulating its transport. Human CRELD2 shares 69% amino acid identity with its mouse counterpart, suggesting a conserved role between species. Multiple isoforms of CRELD2 exist due to alternative splicing events. The gene encoding CRELD2 maps to human chromosome 22, which houses over 500 genes and is the second smallest human chromosome. Mutations in several of the genes that map to chromosome 22 are involved in the development of Phelan-McDermid syndrome, Neurofibromatosis type 2, autism and schizophrenia.
    Please let us know if you have published research using #36370 so that we can cite your reference.
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    Protocol
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    Note
      Application:
    • WBWestern Blotting
    • IHCImmunohistochemistry
    • IFImmunofluorescence
    • ICCImmunocytochemistry
    • FCFlow Cytometry
    • IPImmunoprecipitation
    • EELISA
    • DBDot Blotting
    • ChIPChromatin Immunoprecipitation
    • GICAGold Immunochromatography Assay
    • NCNegative Control
      Species Reactivity:
    • HuHuman
    • MsMouse 
    • RtRat 
    • Dm Drosophila melanogaster
    • C Caenorhabditis elegans
    • MkMonkey
    • RbRabbit
    • B Bovine 
    • D Dog
    • PPig
    • HmHamster
    • ChHm Chinese Hamster 
    • ChkChicken  
    • ShpSheep  
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