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STAT5a(Phospho-Tyr694) Antibody#11048

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Product NameSTAT5a(Phospho-Tyr694) Antibody

Host SpeciesRabbit

ClonalityPolyclonal

PurificationAntibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

ApplicationsWB IHC

Species ReactivityHu Ms Rt

SpecificityThe antibody detects endogenous level of STAT5A only when phosphorylated at tyrosine 694.

Immunogen TypePeptide-KLH

Immunogen DescPeptide sequence around phosphorylation site of tyrosine 694 (D-G-Y(p)-V-K) derived from Human STAT5A.

Target NameSTAT5a

ConjugateUnconjugated

Other NamesMGF; MPF; Mammary gland factor; STA5A,; STAT5

Accession NoSwiss-Prot: P42229
NCBI Protein: NP_003143.2

Uniprot P42229

Gene ID 6776;

Concentration1.0mg/ml

FormulationSupplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

StorageStore at -20°C for long term preservation (recommended). Store at 4°C for short term use.

Application Details
Predicted MW: 90kd
Western blotting: 1:500~1:1000
Immunohistochemistry: 1:50~1:100
Western blot analysis of extracts from K562 cells untreated or treated with G-CSF using STAT5A(Phospho-Tyr694) Antibody #11048.
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using STAT5A(Phospho-Tyr694) Antibody #11048(left) or the same antibody preincubated with blocking peptide(right).
Carries out a dual function: signal transduction and activation of transcription. Binds to the GAS element and activates PRL-induced transcription.

Gouilleux F, et al. (1994) EMBO J. 13: 4361-4369.
Dentelli P, et al. (1999) J Immunol. 163: 2151-2159.
Meinke A, et al. (1996) Mol Cell Biol. 16: 6937-6944.

If you have published an article using product 11048, please notify us so that we can cite your literature.

et al,Characterization of the Rat Oncostatin M Receptor Complex Which Resembles the Human, but Differs from the Murine Cytokine Receptor. , (2012),
PMID: 22937020
et al,A thiazole-derived oridonIn analogue exhibits antitumor activity by directly and allosterically InhibitIng STAT3. In J Biol Chem on 2019 Nov 15;by Shen X, Zhao L,et al..PMID:31594861 , (2019),
PMID: 31594861
et al,Downregulation of CCND1 and CDK6 by miR-34a Induces Cell Cycle Arrest.In FEBS Lett on 2008 Apr 30 by Fang Sun, Hanjiang Fu,et al..PMID:18406353 , (2008),
PMID: 18406353
et al,JAK3 deregulation by activating mutations confers invasive growth advantage in extranodal nasal-type natural killer cell lymphoma.In Leukemia on 2014 Feb by A Bouchekioua 1 , L Scourzic et al..PMID: 23689514 , (2014),
PMID: 23689514
et al, The tyrosine phosphatase SHP2 is required for cell transformation by the receptor tyrosine kinase mutants FIP1L1-PDGFR伪 and PDGFR伪 D842V.In Mol Oncol on 2014 May by Laura A No毛l , Florence A Arts et al..PMID:24618081 , (2016),
PMID: 24618081
et al, PDGFRA alterations in cancer: characterization of a gain-of-function V536E transmembrane mutant as well as loss-of-function and passenger mutations.In Oncogene on 2014 May 15 by A I Velghe, S Van Cauwenberghe et al..PMID:23752188 , (2014),
PMID: 23752188
et al,In-depth analysis of the expression and functions of signal transducers and activators of transcription in human ovarian cancer , (2022),
PMID:

NOTE

Application

  • WBWestern Blotting
  • IHCImmunohistochemistry
  • IFImmunofluorescence
  • ICCImmunocytochemistry
  • FCFlow Cytometry
  • IPImmunoprecipitation
  • EELISA
  • DBDot Blotting
  • ChIPChromatin Immunoprecipitation
  • GICAGold Immunochromatography Assay
  • NCNegative Control

Species Reactivity

  • HuHuman
  • MsMouse
  • RtRat
  • DmDrosophila melanogaster
  • CCaenorhabditis elegans
  • MkMonkey
  • RbRabbit
  • BBovine
  • DDog
  • PPig
  • HmHamster
  • ChHmChinese Hamster
  • ChkChicken
  • ShpSheep
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