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PLCgamma1(Phospho-Tyr783) Antibody#11103

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Product Detail

Product NamePLCgamma1(Phospho-Tyr783) Antibody

Host SpeciesRabbit

ClonalityPolyclonal

PurificationAntibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

ApplicationsWB

Species ReactivityHu Ms Rt

SpecificityThe antibody detects endogenous level of PLCg1 only when phosphorylated at tyrosine 783.

Immunogen TypePeptide-KLH

Immunogen DescPeptide sequence around phosphorylation site of tyrosine 783 (G-F-Y(p)-V-E) derived from Human PLCG1.

Target NamePLCgamma1

ConjugateUnconjugated

Other NamesPhosphoinositide phospholipase C; Phospholipase C-gamma-1;

Accession NoSwiss-Prot: P19174
NCBI Protein: NP_002651.2

Uniprot P19174

Gene ID 5335;

Concentration1.0mg/ml

FormulationSupplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

StorageStore at -20°C for long term preservation (recommended). Store at 4°C for short term use.

Application Details

Predicted MW: 155kd
Western blotting: 1:500~1:1000
 

Western blot analysis of extracts from HL60 cells untreated or treated with EGF using PLCg1(Phospho-Tyr783) Antibody #11103.

PLC-gamma is a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase.

DeBell KE, et al. Mol Cell Biol. 1999 Nov; 19(11): 7388-7398.
Ver

If you have published an article using product 11103, please notify us so that we can cite your literature.

et al,Signal regulatory protein 伪 negatively regulates mast鈥恈ell activation following Fc蔚RI aggregation. In Eur J Immunol on 2013 Jun by Yu-fei Pan, Li-wei Dong, et al..PMID: 23504624 , (2013),
PMID: 23504624
et al,Discovery of a novel inhibitor of the protein tyrosine phosphatase Shp2.In Sci Rep on 2015 Dec 2 by Chuan Chen , Mengmeng Cao et al..PMID: 26626996 , (2015),
PMID: 26626996
et al,Antiproliferative Activity of Hinokitiol, a Tropolone Derivative, Is Mediated via the Inductions of p-JNK and p-PLC纬1 Signaling in PDGF-BB-Stimulated Vascular Smooth Muscle Cells.In Molecules on 2015 May 7 by Po-Sheng Yang, Meng-Jiy Wang et al..PMID: 25961161 , (2015),
PMID: 25961161
et al,Synergistic effects of c-Jun and SP1 in the promotion of TGF尾1-mediated diabetic nephropathy progression.In Exp Mol Pathol on 2016 Jun by Pan Gao, Yingze Wei et al..PMID:27112839 , (2016),
PMID: 27112839
et al,Inhibition of vascular smooth muscle cell proliferation of vitamin E derivative pentamethylhydroxychromane in an in vitro and in vivo study: Pivotal role of hydroxyl radical-mediated PLC 1 and JAK2 phosphorylation. , (2010),
PMID: 20600839
et al,Inhibition of vascular smooth muscle cell proliferation by the vitamin E derivative pentamethylhydroxychromane in an in vitro and in vivo study: pivotal role of hydroxyl radical-mediated PLC 1 and JAK2 phosphorylation. In Free Radic Biol Med on 2010 Sep 1 by Chien-Liang Liu, Ming-Jen Hsu, et al..PMID: 20600839 , (2010),
PMID: 20600839

NOTE

Application

  • WBWestern Blotting
  • IHCImmunohistochemistry
  • IFImmunofluorescence
  • ICCImmunocytochemistry
  • FCFlow Cytometry
  • IPImmunoprecipitation
  • EELISA
  • DBDot Blotting
  • ChIPChromatin Immunoprecipitation
  • GICAGold Immunochromatography Assay
  • NCNegative Control

Species Reactivity

  • HuHuman
  • MsMouse
  • RtRat
  • DmDrosophila melanogaster
  • CCaenorhabditis elegans
  • MkMonkey
  • RbRabbit
  • BBovine
  • DDog
  • PPig
  • HmHamster
  • ChHmChinese Hamster
  • ChkChicken
  • ShpSheep
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