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Tau(Phospho-Ser214) Antibody#11109

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Product NameTau(Phospho-Ser214) Antibody

Host SpeciesRabbit

ClonalityPolyclonal

PurificationAntibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

ApplicationsWB

Species ReactivityHu Ms Rt

SpecificityThe antibody detects endogenous level of Tau only when phosphorylated at serine 214.

Immunogen TypePeptide-KLH

Immunogen DescPeptide sequence around phosphorylation site of serine 214 (T-P-S(p)-L-P) derived from Human Tau.

Target NameTau

ConjugateUnconjugated

Other NamesMAPT; MTAPT; MTBT1; Neurofibrillary tangle protein; PHF-tau

Accession NoSwiss-Prot: P10636
NCBI Protein: NP _001116538.1

Uniprot P10636

Gene ID 4137;

Concentration1.0mg/ml

FormulationSupplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

StorageStore at -20°C for long term preservation (recommended). Store at 4°C for short term use.

Application Details
Predicted MW: 48 62 78 kd
Western blotting: 1:500~1:1000
Western blot analysis of extracts from mouse brain tissue using Tau(Phospho-Ser214) Antibody #11109 and the same antibody preincubated with blocking peptide.
Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.

Smet C, et al. (2005) FEBS Lett; 579(19): 4159-64.
Puig B, et al. (2005) Acta Neuropathol (Berl).
Gvtz J, et al. (2001) Science; 293(5534): 1491-5.
Illenberger S, et al. (1998) Mol Biol Cell; 9(6): 1495-512.

If you have published an article using product 11109, please notify us so that we can cite your literature.

et al,Protection of melatonin against acidosis induced neuronal injuries.In J Cell Mol Med on 2020 May 4 by Shi Y, Cai EL, et al..PMID: 32364678 , (2020),
PMID: 32364678
et al,Tau-Induced Ca2+/Calmodulin-Dependent Protein Kinase-IV Activation Aggravates Nuclear Tau Hyperphosphorylation .In Neurosci Bull. On 2018 Apr by Wei YP, Ye JW et al..PMID: 28646348 , (2018),
PMID: 28646348
et al,Bip enhanced the association of GSK-3尾 with tau during ER stress both in vivo and in vitro. In J Alzheimers Dis on 2012 by Zan-Chao Liu, Zheng-Qi Fu, et al..PMID:22460328 , (2012),
PMID: 22460328
et al,Olfactory Deprivation Hastens Alzheimer-Like Pathologies in a Human Tau-Overexpressed Mouse Model via Activation of cdk5.In Mol Neurobiol.On 2016 Jan by Li K, Liu FF et al..PMID:25465240 , (2016),
PMID: 25465240
et al,Novel multipotent AChEI-CCB attenuates hyperhomocysteinemia-induced memory deficits and Neuropathologies in rats.In J Alzheimers Dis on 2014 by Yiyuan Xia, Rong Liu et al..PMID: 25024319 , (2014),
PMID: 25024319
et al,Extra-virgin olive oil attenuates amyloid-尾 and tau pathologies in the brains of TgSwDI mice. In J Nutr Biochem on 2015 Dec by Hisham Qosa, Loqman A Mohamed,et al..PMID:26344778 , (2015),
PMID: 26344778
et al,Golgin-84-associated Golgi fragmentation triggers tau hyperphosphorylation by activation of cyclin-dependent kinase-5 and extracellular signal-regulated kinase. In Neurobiol Aging on 2014 Jun by Qian Jiang, Lu Wang,et al..PMID: 24368089 , (2014),
PMID: 24368089
More
et al,MAPT/Tau accumulation represses autophagy flux by disrupting IST1-regulated ESCRT-III complex formation: a vicious cycle in Alzheimer neurodegeneration. In Autophagy on 2020 Apr by Qiong Feng, Yu Luo, et al..PMID:31223056 , (2020),
PMID: 31223056
et al,A novel small-molecule PROTAC selectively promotes tau clearance to improve cognitive functions in Alzheimer-like models. In Theranostics on 2021 Mar 11 by Weijin Wang, Qiuzhi Zhou, et al..PMID:33859747 , (2021),
PMID: 33859747
et al,Tau Aggregation-Dependent Lipid Peroxide Accumulation Driven by the hsa_circ_0001546/14-3-3/CAMK2D/Tau Complex Inhibits Epithelial Ovarian Cancer Peritoneal Metastasis. In Adv Sci (Weinh) on 2024 Jun by BinShu Chai, Yong Wu,et al..PMID:38634567 , (2024),
PMID: 38634567

NOTE

Application

  • WBWestern Blotting
  • IHCImmunohistochemistry
  • IFImmunofluorescence
  • ICCImmunocytochemistry
  • FCFlow Cytometry
  • IPImmunoprecipitation
  • EELISA
  • DBDot Blotting
  • ChIPChromatin Immunoprecipitation
  • GICAGold Immunochromatography Assay
  • NCNegative Control

Species Reactivity

  • HuHuman
  • MsMouse
  • RtRat
  • DmDrosophila melanogaster
  • CCaenorhabditis elegans
  • MkMonkey
  • RbRabbit
  • BBovine
  • DDog
  • PPig
  • HmHamster
  • ChHmChinese Hamster
  • ChkChicken
  • ShpSheep
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