Product Detail
Product NameTau(Phospho-Ser262) Antibody
Host SpeciesRabbit
ClonalityPolyclonal
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ApplicationsWB
Species ReactivityHu Ms Rt
SpecificityThe antibody detects endogenous level of Tau only when phosphorylated at serine 262.
Immunogen TypePeptide-KLH
Immunogen DescPeptide sequence around phosphorylation site of serine 262 (I-G-S(p)-T-E) derived from Human Tau.
Target NameTau
ConjugateUnconjugated
Other NamesMAPT; MTAPT; MTBT1; Neurofibrillary tangle protein; PHF-tau
Accession NoSwiss-Prot: P10636
NCBI Protein: NP_001116538.1
Uniprot
P10636
Gene ID
4137;
Calculated MW50-85kD
Concentration1.0mg/ml
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
StorageStore at -20°C for long term preservation (recommended). Store at 4°C for short term use.
Application Details
This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. [provided by RefSeq, Jul 2008],
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et al,FoxO1 overexpression reduces Aβ production and tau phosphorylation in vitro. In Neurosci Lett on 2020 Nov 1 by Wei Zhang, Shanshan Bai,et al..PMID:32860886
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