Product Detail
Product NameTrkB(Phospho-Tyr706) Antibody
Host SpeciesRabbit
ClonalityPolyclonal
PurificationAntibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
ApplicationsWB
Species ReactivityHu Ms Rt
SpecificityThe antibody detects endogenous level of TrkB only when phosphorylated at tyrosine 706.
Immunogen TypePeptide-KLH
Immunogen DescPeptide sequence around phosphorylation site of tyrosine 706 (T-D-Y P-Y-R) derived from Human TrkB.
Target NameTrkB
ConjugateUnconjugated
Other NamesBDNF/NT-3 growth factors receptor precursor; EC 2.7.10.1; GP145-TrkB; GP145-TrkB/GP95-TrkB; NTRK2
Accession NoSwiss-Prot: Q16620
NCBI Protein: NP _001007098.1
Uniprot
Q16620
Gene ID
4915;
Concentration1.0mg/ml
FormulationSupplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
StorageStore at -20°C for long term preservation (recommended). Store at 4°C for short term use.
Application Details
Predicted MW: 140kd
Western blotting: 1:500~1:1000
Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3 and neurotrophin-4/5 but not nerve growth factor (NGF). Involved in the development and/or maintenance of the nervous system. This is a tyrosine-protein kinase receptor. Known substrates for the TRK receptors are SHC1, PI-3 kinase, and PLC-gamma-1.
Woronowicz A, et al. Glycobiology. 2007 Jan;17(1):10-24.
Mojsilovic-Petrovic J, et al. J Neurosci. 2006 Sep 6;26(36):9250-63.
Lewis MA, et al. Mol Pharmacol. 2006 Apr;69(4):1396-404.
Cai D, et al. Physiol Genomics. 2006 Feb 14;24(3):191-7.
If you have published an article using product 11328, please notify us so that we can cite your literature.
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et al,A small molecule TrkB ligand reduces motor impairment and neuropathology in R6/2 and BACHD mouse models of Huntington's disease. In J Neurosci on 2013 Nov 27
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on 2012 May 3 by YeeWen Candace Wu, Rachel A Hill, et al..PMID:22464183
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et al,Sex-dependent and region-specific changes in TrkB signaling in BDNF heterozygous mice. In Brain Res on 2011 Apr 12 by Rachel A Hill, Maarten van den Buuse锟?et al..PMID: 21281620
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et al,Chronic Intermittent Hypobaric Hypoxia Pretreatment Ameliorates Ischemia-Induced Cognitive Dysfunction Through Activation of ERK1/2-CREB-BDNF Pathway in Anesthetized Mice.In Neurochem Res on 2017 Feb by Jintian Wang , Shixiao Zhang,et al..PMID: 27822668
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et al,ER伪 Signaling Is Required for TrkB-Mediated Hippocampal Neuroprotection in Female Neonatal Mice after Hypoxic Ischemic Encephalopathy. In eNeuro on 2016 Jan 28 by Ulas Cikla, Vishal Chanana, et al..PMID: 26839918
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et al,Long-term effects of combined neonatal and adolescent stress on brain-derived neurotrophic factor and dopamine receptor expression in the rat forebrain.In Biochim Biophys Acta on 2014 Nov by Rachel A Hill, Szerenke Kiss Von Soly ,et al..PMID:25159716
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et al,Sex鈥恠pecific disruptions in spatial memory and anhedonia in a 鈥渢wo hit锟?rat model correspond with alterations in hippocampal brain鈥恉erived neurotrophic factor expression and signaling. In Hippocampus on 2014 Oct by Rachel A Hill, Maren Klug,et al..PMID:24802968
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et al,Brain-derived neurotrophic factor heterozygous mutant rats show selective cognitive changes and vulnerability to chronic corticosterone treatment. In Neuroscience on 2015 Jan 22 by A Gururajan, R A Hill,et al..PMID:25445195
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et al,17β-estradiol activation of dorsal hippocampal TrkB is independent of increased mature BDNF expression and is required for enhanced memory consolidation in female mice. In Psychoneuroendocrinology on 2021 Mar by Kellie S Gross, Randie L Alf, et al..PMID:33352471
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et al,VPS13A knockdown impairs corticostriatal synaptic plasticity and locomotor behavior in a new mouse model of chorea-acanthocytosisIn Neurobiol DisOn2023 Oct 15byEsther García-García , Alba Ramón-Lainez et al..PMID:37714309
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et al,Neuron-derived extracellular vesicles contain synaptic proteins, promote spine formation, activate TrkB-mediated signalling and preserve neuronal complexityInJ Extracell VesiclesOn2023 SepbyJulia Solana-Balaguer , Genís Campoy-Campos et al..PMID:37743539
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et al,Investigating 7, 8-Dihydroxyflavone to combat maternal immune activation effects on offspring gene expression and behaviour. In Prog Neuropsychopharmacol Biol Psychiatry on 2024 Aug 30 by Brendan Gillespie, Ariel Dunn, et al..PMID:38950841
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et al,Loss of Adaptive Myelination Contributes to Methotrexate Chemotherapy-Related Cognitive Impairment
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