Product Detail
Product NameTERT (phospho Ser227) Polyclonal Antibody
Host SpeciesRabbit
ClonalityPolyclonal
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ApplicationsIF/ICC,ELISA
Species ReactivityHuman
SpecificityPhospho-TERT (S227) Polyclonal Antibody detects endogenous levels of TERT protein only when phosphorylated at S227.
Immunogen DescThe antiserum was produced against synthesized peptide derived from human Telomerase around the phosphorylation site of Ser227. AA range:196-245
ConjugateUnconjugated
Other NamesTERT; EST2; TCS1; TRT; Telomerase reverse transcriptase; HEST2; Telomerase catalytic subunit; Telomerase-associated protein 2; TP2
Accession NoSwiss Prot:O14746
GeneID:7015
Uniprot
O14746
Gene ID
7015
Calculated MW126kd
Concentration1 mg/ml
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage-20˚C/1
Application Details
Immunofluorescence: 1/200 - 1/1000.
ELISA: 1/10000. Not yet tested in other applications.
telomerase reverse transcriptase(TERT) Homo sapiens Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified; the full-length sequence of some variants has not been determined. Alternative sp
If you have published an article using product 13485, please notify us so that we can cite your literature.
et al,Fructose-1,6-bisphosphatase 1 dephosphorylates and inhibits TERT for tumor suppression. In Nat Chem Biol on 2024 Nov
by Min Li, Zheng Wang,et al..PMID:38538923
, (2024),
PMID:
38538923
Yes
