Product Detail
Product NameMKP-1 (phospho Ser359) Polyclonal Antibody
Host SpeciesRabbit
ClonalityPolyclonal
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ApplicationsIHC-p,IF(paraffin section),ELISA
Species ReactivityHuman
SpecificityPhospho-MKP-1 (S359) Polyclonal Antibody detects endogenous levels of MKP-1 protein only when phosphorylated at S359.
Immunogen DescThe antiserum was produced against synthesized peptide derived from human MKP1 around the phosphorylation site of Ser359. AA range:318-367
ConjugateUnconjugated
Other NamesDUSP1; CL100; MKP1; PTPN10; VH1; Dual specificity protein phosphatase 1; Dual specificity protein phosphatase hVH1; Mitogen-activated protein kinase phosphatase 1; MAP kinase phosphatase 1; MKP-1; Protein-tyrosine phosphatase CL100
Accession NoSwiss Prot:P28562
GeneID:1843
Uniprot
P28562
Gene ID
1843
Calculated MW39kd
Concentration1 mg/ml
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage-20˚C/1
Application Details
Immunohistochemistry: 1/100 - 1/300.
ELISA: 1/10000. Not yet tested in other applications.
dual specificity phosphatase 1(DUSP1) Homo sapiens The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferati
If you have published an article using product 13706, please notify us so that we can cite your literature.
et al,DUSP1/MKP-1 represents another piece in the P2X7R intracellular signaling puzzle in cerebellar cells: our last journey with Ma Teresa along the purinergic pathways of EdenInPurinergic SignalOn2023 Sep 30byJuan Carlos Gil-Redondo et al..PMID:?37776398
, (2023),
PMID:
37776398
et al,DUSP1/MKP-1 represents another piece in the P2X7R intracellular signaling puzzle in cerebellar cells: our last journey with Mª Teresa along the purinergic pathways. In Purinergic Signal on 2024 Apr by Juan Carlos Gil-Redondo, María José Queipo, et al..PMID:37776398
, (2024),
PMID:
37776398
Yes
