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Akt(Ab-473) Antibody#21054

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Product NameAkt(Ab-473) Antibody

Host SpeciesRabbit

ClonalityPolyclonal

PurificationAntibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

ApplicationsWB IHC IF

Species ReactivityHu Ms Rt

SpecificityThe antibody detects endogenous level of total Akt protein.

Immunogen TypePeptide-KLH

Immunogen DescPeptide sequence around aa. 471~475 (Q-F-S-Y-S) derived from Human Akt.

Target NameAkt

ConjugateUnconjugated

Other NamesAKT; C-AKT; PKB; PKB-alpha; RAC

Accession NoSwiss-Prot: P31749
NCBI Protein: NP_001014431.1

Uniprot P31749

Gene ID 207;

Concentration1.0mg/ml

FormulationSupplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

StorageStore at -20°C for long term preservation (recommended). Store at 4°C for short term use.

Application Details

Predicted MW: 60kd
Western blotting: 1:500~1:1000
Immunohistochemistry: 1:50~1:100

Western blot analysis of extracts from 293 and 3T3 cells using Akt(Ab-473) Antibody #21054.
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using Akt(Ab-473) Antibody #21054(left) or the same antibody preincubated with blocking peptide(right).
Western blot analysis of extracts of various cell lines, using Akt(Ab-473) #21054

General protein kinase capable of phosphorylating several known proteins. Phosphorylates TBC1D4. Signals downstream of phosphatidylinositol 3-kinase (PI3K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). Plays a role in glucose transport by mediating insulin-induced translocation of the GLUT4 glucose transporter to the cell surface. Mediates the antiapoptotic effects of IGF-I. Mediates insulin-stimulated protein synthesis by phosphorylating TSC2 at 'Ser-939' and 'Thr-1462', thereby activating mTORC1 signaling and leading to both phosphorylation of 4E-BP1 and in activation of RPS6KB1. Promotes glycogen synthesis by mediating the insulin-induced activation of glycogen synthase.

Baudhuin LM, et al. (2004) FASEB J Feb; 18(2): 341-3.
Min YH, et al. (2004) Cancer Res; 64(15): 5225-31.
Feng J, et al. (2004) J Biol Chem; 279(34): 35510-7.
Ayala G, et al. (2004) Clin Cancer Res; 10(19): 6572-8.
Lungu AO, et al. (2004) J Biol Chem; 279(47): 48794-800.

If you have published an article using product 21054, please notify us so that we can cite your literature.

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et al,Canonical notch pathway protects hepatocytes from ischemia/reperfusion injury in mice by repressing reactive oxygen species production through JAK2/STAT3 signaling.In Hepatology on 2011 Sep 2 by Yu HC, Qin HY,et al..PMID:21633967 , (2011),
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et al,Loss of Fatty Acid Synthase Inhibits the "HER2-PI3K/Akt Axis" Activity and Malignant Phenotype of Caco-2 Cells.In Lipids Health Dis on 2013 Jun 1 by Nan Li, Heng Lu,et al..PMID:23725225 , (2013),
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et al,FAM129B/MINERVA, a novel adherens junction-associated protein, suppresses apoptosis in HeLa cells. In J Biol Chem on 2011 Mar 25 by Song Chen, Hedeel Guy Evans, et al..PMID: 21148485 , (2011),
PMID: 21148485
et al,Transforming growth factor 尾 induces expression of connective tissue growth factor in hepatic progenitor cells through Smad independent signaling. In Cell Signal on 2013 Oct by Ze-yang Ding , Guan-nan Jin, et al..PMID: 23727026 , (2013),
PMID: 23727026
et al,The 鈥淗ER2鈥揚I3K/Akt鈥揊ASN Axis锟?Regulated Malignant Phenotype of Colorectal Cancer Cells. In Lipids on 2012 Apr by Nan Li, Xiaodong Bu, et al..PMID:22218925 , (2012),
PMID: 22218925
et al,A Proteomic approach for protein鈥恜rofiling the oncogenic ras induced transformation (H锟? K锟? and N鈥怰as) in NIH/3T3 mouse embryonic fibroblasts. In Proteomics on 2008 Aug by Seyoon Kim, Yong Zu Lee, et al..PMID:18601226 , (2008),
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et al,Costunolide improved dextran sulfate sodium-induced acute ulcerative colitis in mice through NF-kB, STAT1/3, and Akt signaling pathways. In Int Immunopharmacol on 2020 Jul by Fan Xie, Hai Zhang, et al..PMID:32413737 , (2020),
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NOTE

Application

  • WBWestern Blotting
  • IHCImmunohistochemistry
  • IFImmunofluorescence
  • ICCImmunocytochemistry
  • FCFlow Cytometry
  • IPImmunoprecipitation
  • EELISA
  • DBDot Blotting
  • ChIPChromatin Immunoprecipitation
  • GICAGold Immunochromatography Assay
  • NCNegative Control

Species Reactivity

  • HuHuman
  • MsMouse
  • RtRat
  • DmDrosophila melanogaster
  • CCaenorhabditis elegans
  • MkMonkey
  • RbRabbit
  • BBovine
  • DDog
  • PPig
  • HmHamster
  • ChHmChinese Hamster
  • ChkChicken
  • ShpSheep
;

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