Product Detail
Product NameSlug Antibody
Host SpeciesRabbit
ClonalityPolyclonal
PurificationAffinity chromatography purified via peptide column
ApplicationsELISA WB IF
Species ReactivityHu Ms
Immunogen TypePeptide
Immunogen DescRaised against a 13 amino acid peptide from near the center of human Slug.
Target NameSlug
ConjugateUnconjugated
Other NamesNeural crest transcription factor slug, Snail homolog 2
Accession NoO43623
Uniprot
O43623
Gene ID
6591;
Concentration1mg/ml
FormulationSupplied in PBS containing 0.02% sodium azide.
StorageCan be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Application Details
Western blot analysis of Slug in 293 cell lysate with Slug antibody at in (A) 0.5, (B) 1 and (C) 2 ug/mL.
Immunofluorescence of Slug in human kidney tissue with Slug antibody at 20 ug/mL.
Slug, a member of the Snail family of C2H2-type zinc finger transcription factors, was initially identified to be involved in epithelial-mesenchymal transitions as well as the formation of the neural tube during vertebrate embryogenesis. Like Snail, Slug transcription can be induced by growth factors such as FGF, BMP, and TGF-beta. Once expressed, Slug will bind E-box regions of promoters and repress transcription of genes such as E-cadherin and Claudin-. More recently, its expression in breast, esophogeal, and colorectal carcinomas has been correlated with poor prognosis for survival. Furthermore, Slug can protect hemapoietic progenitor cells from radiation-induced apoptosis by repressing the p53-mediated transcription of Puma, a BH3-only antagonist of the anti-apoptotic members of the Bcl-2 family. Slug antibody has no cross-reactivity to Snail protein.
If you have published an article using product 24463, please notify us so that we can cite your literature.
et al,Nanosized functional miRNA liposomes and application In the treatment of TNBC by silencIng Slug gene. In Int J NanomedicIne. on 2019 May 17 by Yan Y, Li XQ, et al..PMID:31190817
, (2019),
PMID:
31190817
et al,Glycogen Phosphorylase B Is Regulated by miR101-3p and Promotes Hepatocellular Carcinoma Tumorigenesis. In Front Cell Dev Biol on 2020 Nov 25 by Guangying Cui, Huifen Wang, et al..PMID:33324633
, (2020),
PMID:
33324633
et al,Novel long noncoding RNA LINC02820 augments TNF signaling pathway to remodel cytoskeleton and potentiate metastasis in esophageal squamous cell carcinoma. In Cancer Gene Ther on 2022 Nov 10 by Jing Wang, Tie-Jun Huang, et al..PMID:36357564
, (2022),
PMID:
36357564
et al,Novel long noncoding RNA LINC02820 augments TNF signaling pathway to remodel cytoskeleton and potentiate metastasis in esophageal squamous cell carcinomaInCancer Gene TherOn2023 FebbyJing Wang?1,?Tie-Jun Huang et al..PMID:?36357564
, (2023),
PMID:
36357564
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