Product Detail
Product NameLKB1 Antibody
Host SpeciesRabbit
ClonalityPolyclonal
PurificationAffinity chromatography purified via peptide column
ApplicationsELISA WB
Species ReactivityHu Ms
Immunogen TypePeptide
Immunogen DescRaised against a 15 amino acid peptide from near the carboxy terminus of human LKB1.
Target NameLKB1
ConjugateUnconjugated
Other NamesSerine-threonine protein kinase 11, STK11, NT-REN-19 antigen
Accession NoSwiss-Prot:Q15831
Gene ID:6794
Uniprot
Q15831
Gene ID
6794;
Concentration1mg/ml
FormulationSupplied in PBS containing 0.02% sodium azide.
StorageCan be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Application Details
Western blot analysis of LKB1 in PC-3 cell lysate with LKB1 antibody at 1 ug/mL in the (A) absence or (B) presence of blocking peptide.
The LKB1 serine/threonine protein kinase was initially identified as a tumor suppressor gene mutated in human Peutz-Jeghers syndrome (PJS), a condition resulting in the growth of numerous intestinal polyps classed as hamartomas. LKB1 exists as a heterotrimeric complex with two other proteins, Ste20-related adaptor protein (STRAD) and MO25. Together, this complex can phsophorylate and activate the AMP-activate protein kinase (AMPK). Following AMPK activation by LKB1, AMPK then phosphorylates TSC1 and TSC2, key components of the metabolism-regulating TOR signaling pathway, which antagonizes the activation for the TOR pathway. LKB1 has also been shown to play a fundamental role in controlling the spatial orientation of structures required to maintain an ordered, polarized epithelium.
If you have published an article using product 24473, please notify us so that we can cite your literature.
et al,Artemisinin conferred cytoprotection to human retinal pigment epithelial cells exposed to amiodarone-induced oxidative insult by activating the CaMKK2/AMPK/Nrf2. In J Transl Med on 2024 Sep 16 by Chao Yang, Xia Zhao,et al..PMID:39285426
, (2024),
PMID:
39285426
Yes
