Product Detail
Product NameIFN-beta Antibody
Host SpeciesRabbit
ClonalityPolyclonal
PurificationAffinity chromatography purified via peptide column
ApplicationsELISA WB IHC
Species ReactivityHu Ms
Immunogen TypePeptide
Immunogen DescRaised against a 17 amino acid peptide from near the center of human IFN-b.
Target NameIFN-beta
ConjugateUnconjugated
Other NamesInterferon beta, beta-interferon
Accession NoSwiss-Prot:P01574
Gene ID:3456
Uniprot
P01574
Gene ID
3456;
Concentration1mg/ml
FormulationSupplied in PBS containing 0.02% sodium azide.
StorageCan be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Application Details
Western blot analysis of IFN-b in A-20 cell lysate with IFN-b antibody at 5 ug/mL.
Immunohistochemistry of IFN-b in human liver tissue with IFN-b antibody at 5 ug/mL.
Type I Interferons (IFN-alpha/beta) are produced primarily in response to viral infection by "Natural IFN-producing cells" (IPCs) as part of the host immune response and can also inhibit the development of tumors. IFN-beta binding by its receptor results in the activation of the tyrosine kinases Jak1 and Tyk2 and phosphorylation of members of the STAT family of transcription factors, leading to the transcription and expression of the immune response genes. More recently, several members of the toll-like receptor (TLR) family were found to stimulate the production IFN-beta. IFN-beta is currently used clinically for treatment of tumors, infections and multiple sclerosis.
If you have published an article using product 24540, please notify us so that we can cite your literature.
et al,Sustained induction of IP-10 by MRP8/14 via the IFNβ–IRF7 axis in macrophages exaggerates lung injury in endotoxemic mice
, (2023),
PMID:
37701855
Yes
