Product Detail
Product NameCCDC106 Antibody
Host SpeciesRabbit
ClonalityPolyclonal
PurificationAffinity chromatography purified via peptide column
ApplicationsELISA WB IHC
Species ReactivityHu Ms Rt
Immunogen TypePeptide
Immunogen DescRaised against a 15 amino acid peptide near the carboxy terminus of human CCDC106.
Target NameCCDC106
ConjugateUnconjugated
Other NamesCoiled-coil domain containing protein 106, ZNF581, HSU79303
Accession NoSwiss-Prot:Q9BWC9
Gene ID:29903
Uniprot
Q9BWC9
Gene ID
29903;
Concentration1mg/ml
FormulationSupplied in PBS containing 0.02% sodium azide.
StorageCan be stored at -20˚C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Application Details
Western blot analysis of CCDC106 in human brain tissue lysate with CCDC106 antibody at (A) 0.5 and (B) 1 ug/mL.
Immunohistochemistry of CCDC106 in rat brain tissue with CCDC106 antibody at 5 ug/mL.
The coiled-coil domain is a common protein motif that is often involved in protein oligomerization and is found in proteins such as transcription factors and intermediate filaments. CCDC106 was initially identified as a p53-interacting protein by yeast two-hybrid screening. Other experiments demonstrated that CCDC106 co-localizes and interacts with p53 in the nucleus, inhibiting the transcriptional activity of p53 and stimulating p53 protein degradation, indicating that at least one of the functions of CCDC106 is acting as a negative regulator of p53.
If you have published an article using product 25162, please notify us so that we can cite your literature.
et al,CK2-mediated CCDC106 phosphorylation is required for p53 degradation In cancer progression. In J Exp ClIn Cancer Res on 2019 Mar 18 by NIng Y, Wang C, et al..PMID: 30885251
, (2019),
PMID:
30885251
Yes
