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DC-SIGN Monoclonal Antibody#26004

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Product Detail

Product NameDC-SIGN Monoclonal Antibody

Clone No.mAb (Clone 8B6)

Host SpeciesMouse

ClonalityMonoclonal

PurificationImmunoaffinity chromotography purified IgG

ApplicationsELISA WB IHC

Species ReactivityHu

Immunogen TypeRecombinant protein

Immunogen DescA recombinant His-tagged protein fragment corresponding to the extracellular region of human DC-SIGN.

Target NameDC-SIGN

ConjugateUnconjugated

Other NamesDC-SIGN (8B6), Dendritic cell-specific ICAM-3-grabbing nonintegrin 1

Accession NoQ9NNX6

Uniprot Q9NNX6

Gene ID 30835;

Concentration1mg/ml

FormulationSupplied in PBS containing 0.02% sodium azide.

StorageCan be stored at -20˚C, stable for one year.

Application Details
Western blot detection of DC-SIGN fusion protein in human uterus tissue lysate at (A) 1 and (B) 2 ug/mL.
Immunohistochemistry of DC-SIGN in lymph node tissue with DC-SIGN antibody at 10 ug/mL.
Dendritic cells (DCs) that control immune responses were recently found to capture and transport HIV from the mucosal area to remote lymph nodes , where DCs hand over HIV to CD4+ T lymphocytes. DCs also amplify the amount of virus and extend the duration of viral infectivity. Multiple strains of HIV-1, HIV-2 and SIV bind to DCs via DC-SIGN. ICAM-3 is the natural ligand for DC-SIGN. A DC-SIGN homologue (termed DC-SIGNR, L-SIGN, and DC-SIGN2) was identified recently. DC-SIGN forms a novel gene family with DC-SIGNR and many alternatively spliced isoforms of DC-SIGN and DC-SIGNR are known to exisit (8). The expression of DC-SIGN was found in mucosal tissues including placenta, small intestine, and rectum.

If you have published an article using product 26004, please notify us so that we can cite your literature.

NOTE

Application

  • WBWestern Blotting
  • IHCImmunohistochemistry
  • IFImmunofluorescence
  • ICCImmunocytochemistry
  • FCFlow Cytometry
  • IPImmunoprecipitation
  • EELISA
  • DBDot Blotting
  • ChIPChromatin Immunoprecipitation
  • GICAGold Immunochromatography Assay
  • NCNegative Control

Species Reactivity

  • HuHuman
  • MsMouse
  • RtRat
  • DmDrosophila melanogaster
  • CCaenorhabditis elegans
  • MkMonkey
  • RbRabbit
  • BBovine
  • DDog
  • PPig
  • HmHamster
  • ChHmChinese Hamster
  • ChkChicken
  • ShpSheep
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