Product Detail
Product NameBim Monoclonal Antibody
Clone No.mAb (Clone 1C2H4)
Host SpeciesMouse
ClonalityMonoclonal
PurificationImmunoaffinity chromotography purified IgG
ApplicationsELISA WB ICC
Species ReactivityHu Ms Rt
Immunogen TypeRecombinant protein
Immunogen DescRaised against a recombinant protein corresponding to amino acids 2 to 198 of human Bim.
Target NameBim
ConjugateUnconjugated
Other NamesBim (1C2H4): Bcl-2 interacting protein, Bcl-2-related ovarian death gene, BOD, Bcl-2-like 11
Accession NoSwiss-Prot:O43521
Gene ID:10018
Uniprot
O43521
Gene ID
10018;
Concentration1mg/ml
FormulationSupplied in PBS containing 0.02% sodium azide.
StorageCan be stored at -20˚C, stable for one year.
Application Details
Western blot analysis of 5 ng of Bim recombinant protein with Bim antibody at 1 ug/mL.
Immunocytochemistry of Bim in K562 cells with Bim antibody at 10 ug/mL.
Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bcl-2 homology 3 (BH3) domain is a potent death domain. BH3 domain containing pro-apoptotic proteins, including Bad, Bax, Bid, Bik, and Hrk, form a growing subclass of the Bcl-2 family. Bim is another BH3 domain containing protein which can induce apoptosis. Bim interacts with diverse members in the pro-survival Bcl-2 sub-family including Bcl-2, Bcl-xL and Bcl-w. The messenger RNA of Bim is ubiquitously expressed in multiple tissues and cell lines.
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