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XBP-1 Monoclonal Antibody#26031

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Product Detail

Product NameXBP-1 Monoclonal Antibody

Clone No.mAb (Clone 9B7E5)

Host SpeciesMouse

ClonalityMonoclonal

PurificationImmunoaffinity chromotography purified IgG

ApplicationsELISA WB ICC

Species ReactivityHu Ms Rt

Immunogen TypeRecombinant protein

Immunogen DescRaised against recombinant protein corresponding to amino acids 2 to 160 of human XBP-1.

Target NameXBP-1

ConjugateUnconjugated

Other NamesXBP-1 (9B7E5), X box binding protein 1, Tax-responsive element binding protein 5

Accession NoSwiss-Prot:P17861
Gene ID:7494

Uniprot P17861

Gene ID 7494;

Concentration1mg/ml

FormulationSupplied in PBS containing 0.02% sodium azide.

StorageCan be stored at -20˚C, stable for one year.

Application Details
Western blot analysis of 100 ng of XBP-1 recombinant protein with XBP-1 antibody at 1 ug/mL.
Immunocytochemistry of XBP-1 in HepG2 cells with XBP-1 antibody at 2 ug/mL.
X box binding protein 1 (XBP-1) is a key protein in the mammalian unfolded protein response (UPR) that protects the cell against the stress of malfolded proteins in the endoplasmic reticulum (ER). Upon sensing unfolded proteins, an ER transmembrane endonuclease and kinase termed IRE1p is activated and excises an intron from XBP-1 mRNA. The spliced XBP-1 mRNA results in a 371 amino acid protein (XBP-1s) which is then translocated to the nucleus where it binds to the regulatory elements of downstream genes. Together with other UPR transcription factors such as ATF6, XBP-1 stimulates the production of ER stress proteins including the ER resident protein chaperones glucose regulated protein (GRP) 78 and GRP94.

If you have published an article using product 26031, please notify us so that we can cite your literature.

NOTE

Application

  • WBWestern Blotting
  • IHCImmunohistochemistry
  • IFImmunofluorescence
  • ICCImmunocytochemistry
  • FCFlow Cytometry
  • IPImmunoprecipitation
  • EELISA
  • DBDot Blotting
  • ChIPChromatin Immunoprecipitation
  • GICAGold Immunochromatography Assay
  • NCNegative Control

Species Reactivity

  • HuHuman
  • MsMouse
  • RtRat
  • DmDrosophila melanogaster
  • CCaenorhabditis elegans
  • MkMonkey
  • RbRabbit
  • BBovine
  • DDog
  • PPig
  • HmHamster
  • ChHmChinese Hamster
  • ChkChicken
  • ShpSheep
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