Product Detail
Product NameIL-33 Monoclonal Antibody
Clone No.mAb (Clone 12H6D12)
Host SpeciesMouse
ClonalityMonoclonal
PurificationImmunoaffinity chromotography purified IgG
ApplicationsELISA WB IHC
Species ReactivityHu Ms
Immunogen TypeRecombinant protein
Immunogen DescRaised against the recombinant IL-33 protein.
Target NameIL-33
ConjugateUnconjugated
Other NamesIL-33 (12H6D12), Interleukin-33, Nuclear factor from high endothelial venules, NFHEV
Accession NoSwiss-Prot:O95760
Gene ID:90865
Uniprot
O95760
Gene ID
90865;
Concentration1mg/ml
FormulationSupplied in PBS containing 0.02% sodium azide.
StorageCan be stored at -20˚C, stable for one year.
Application Details
Western blot analysis of IL-33 using 125ng of recombinant IL-33 with IL-33 antibody at 1 ug/mL.
Immunohistochemistry of IL-33 in human lymph node tissue with IL-33 antibody at 5 ug/mL.
Interleukin-33 (IL-33) is a recently identified member of the IL-1 family of cytokines whose other members include IL-1αβ, IL-1Ra and IL-18. Its receptor has been shown to be ST2, an IL-1 receptor family member that also acts as a negative regulator of TLR-IL-1R signaling and IL-1R accessory protein (IL-1RAcP). Receptor binding of IL-33 activates NF-κB and MAP kinases and induces the expression of TH2-associated cytokines such as IL-4, IL-5 and IL-6. Prolonged IL-33 treatment of mice led to the development of eosinophilia, splenomegaly, and severe pathological changes in mucosal organs such as lungs, esophagus and small intestine. Recent experiments have shown that IL-33 can also co-localize with heterochromatin and possesses transcriptional repressor activities, indicating that IL-33 may function as both a proinflammatory cytokine and an intracellular nuclear factor with transcriptional regulatory properties. Despite its predicted molecular weight, IL-33 will often run at higher molecular weight in SDS-PAGE.
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