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PD-1 Monoclonal Antibody#26035

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Product Detail

Product NamePD-1 Monoclonal Antibody

Clone No.mAb (Clone 12A7D7)

Host SpeciesMouse

ClonalityMonoclonal

PurificationImmunoaffinity chromotography purified IgG

ApplicationsELISA WB IHC

Species ReactivityHu Ms Rt

Immunogen TypeRecombinant Protein

Immunogen DescA ~150 amino acid recombinant protein from near the terminus terminus of mouse PD-1.

Target NamePD-1

ConjugateUnconjugated

Other NamesPD-1 (12A7D7), Programmed cell death 1, PDCD-1, CD279

Accession NoSwiss-Prot:Q15116
Gene ID:5133

Uniprot Q15116

Gene ID 5133;

Concentration1mg/ml

FormulationSupplied in PBS containing 0.02% sodium azide.

StorageAntibody can be stored at 4°C up to one year. Antibodies should not be exposed to prolonged high temperatures.

Application Details
Western blot analysis of PD-1 in A-20 cell lysate with PD-1 antibody at 1 ug/mL.
Immunohistochemistry of PD-1 in mouse brain tissue with PD-1 antibody at 2.5 ug/mL.

Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antig en-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PDL-1 and PDL-2. Upon binding to either of these ligands, signals generated by PD-1 inhibit the activation of the immune response in the absence of "danger signals" such as LPS or other molecules associated with bacteria or other pathogens. Evidence for this is seen in PD1-null mice who exhibit hyperactivated immune systems and autoimmune diseases. Despite its predicted molecular weight, PD-1 often migrates at higher molecular weight in SDS-PAGE.

If you have published an article using product 26035, please notify us so that we can cite your literature.

NOTE

Application

  • WBWestern Blotting
  • IHCImmunohistochemistry
  • IFImmunofluorescence
  • ICCImmunocytochemistry
  • FCFlow Cytometry
  • IPImmunoprecipitation
  • EELISA
  • DBDot Blotting
  • ChIPChromatin Immunoprecipitation
  • GICAGold Immunochromatography Assay
  • NCNegative Control

Species Reactivity

  • HuHuman
  • MsMouse
  • RtRat
  • DmDrosophila melanogaster
  • CCaenorhabditis elegans
  • MkMonkey
  • RbRabbit
  • BBovine
  • DDog
  • PPig
  • HmHamster
  • ChHmChinese Hamster
  • ChkChicken
  • ShpSheep
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