Product Detail
Product NameCD4 Monoclonal Antibody
Clone No.mAb (Clone 9H5A8)
Host SpeciesMouse
ClonalityMonoclonal
PurificationImmunoaffinity chromotography purified IgG
ApplicationsELISA WB
Species ReactivityHu Ms Rt
Immunogen TypeRecombinant protein
Immunogen DescRaised against a 193 amino acid recombinant protein from near the amino terminus of human CD4.
Target NameCD4
ConjugateUnconjugated
Other NamesCD4 (9H5A8), CD4 antigen, CD4 receptor
Accession NoSwiss-Prot:P01730
Gene ID:920
Uniprot
P01730
Gene ID
920;
Concentration1mg/ml
FormulationSupplied in PBS containing 0.02% sodium azide.
StorageCan be stored at -20˚C, stable for one year.
Application Details
Western blot analysis of CD4 in human thymus tissue lysate with CD4 antibody at (A) 0.5 and (B) 1 ug/mL.
Immunohistochemistry of CD4 in human thymus tissue with CD4 antibody at 5 μg/ml.
CD4 is a member of the immunoglobulin superfamily and is implicated as associative recognition element in MHC (Major Histocompatibility Complex) class II-restricted immune response. On T-lymphocytes, it defines the helper/inducer subset. The mature 55 kd CD4 protein consists of a 372 amino acid extracellular segment composed of four tandem immunoglobulin-like VJ regions. The CD4 molecule is a major receptor for human immunodeficiency virus (HIV), binding directly to the envelope glycoprotein gp120 on HIV, with the co-receptors being CCR5 or CXCR4. It has been shown that the V-like domains are critical for binding with HIV envelope gp120.
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